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All Outputs (262)

Defining the recommended gray zone in MGMT promoter methylation pyrosequencing reporting: A robust translatable method to implement new EANO guidelines (2025)
Journal Article

Background
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) may cause resistance of tumour cells to alkylating agents, and is a predictive biomarker in high-grade gliomas treated with temozolomide. Recent EANO guidelines recommen... Read More about Defining the recommended gray zone in MGMT promoter methylation pyrosequencing reporting: A robust translatable method to implement new EANO guidelines.

Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study (2025)
Journal Article

Introduction Prepectoral techniques are becoming standard of care for implant-based breast reconstruction due to reduced impact on chest wall function and improved patient satisfaction. Evidence to support these benefits, however, is lacking. Here, p... Read More about Patient-reported outcomes 3 and 18 months after mastectomy and immediate prepectoral implant-based breast reconstruction in the UK Pre-BRA prospective multicentre cohort study.

Representation matters: Exposure to advertisements featuring models with different skin shades affects body image, well-being and advertising effectiveness among South Asian Women in the UK (2025)
Journal Article

Racialised appearance ideals displayed in media and advertising imagery privilege white or light skin. Yet, little research has tested how white or light skin ideals in advertising influence body image. In this online experimental study, South Asian... Read More about Representation matters: Exposure to advertisements featuring models with different skin shades affects body image, well-being and advertising effectiveness among South Asian Women in the UK.

Prospective real world data evaluation of clinical outcomes in metastatic hormone sensitive prostate cancer (MHSPC) patients treated as part of triplet therapy with darolutamide: UK multicenter RECOMMEND study (2025)
Journal Article

89 Background: Darolutamide has authorisation for treatment of metastatic hormone sensitive prostate cancer (MHSPC) in combination with docetaxel chemotherapy and androgen deprivation therapy (triplet therapy) based on ARASENS trial results. The RECO... Read More about Prospective real world data evaluation of clinical outcomes in metastatic hormone sensitive prostate cancer (MHSPC) patients treated as part of triplet therapy with darolutamide: UK multicenter RECOMMEND study.

Efficacy outcomes 12 months after initiation of darolutamide in non-metastatic castrate resistant prostate cancer (nmCRPC) from the real world UK multi-centre RECORD study (2025)
Journal Article

83 Background: Darolutamide has authorisation for treatment of non-metastatic Castrate Resistant Prostate Cancer (nmCRPC) based on the ARAMIS trial. The RECORD Study is a prospective real-world evaluation (RWE) of clinical outcomes in patients with n... Read More about Efficacy outcomes 12 months after initiation of darolutamide in non-metastatic castrate resistant prostate cancer (nmCRPC) from the real world UK multi-centre RECORD study.

Body image and appearance distress among military veterans and civilians with an injury-related visible difference: A comparison study (2025)
Journal Article

Injuries sustained during military conflict can significantly impact appearance. Yet, little is known about the psychosocial experiences of veterans with conflict-related appearance-altering injuries (AAI) and whether current civilian interventions a... Read More about Body image and appearance distress among military veterans and civilians with an injury-related visible difference: A comparison study.

A comic-based body image intervention for adolescents in semi-rural Indian schools: A randomised controlled trial (2025)
Journal Article

Adolescents in India experience body dissatisfaction and its associated adverse impacts on physical and mental health and gender equality. However, evidence-based interventions are scarce. Mental health interventions worldwide have traditionally reli... Read More about A comic-based body image intervention for adolescents in semi-rural Indian schools: A randomised controlled trial.

"My body is amazing from the bottom to the top" - An RCT study testing two positive body image media micro-interventions for young children aged 4-6 years (2025)
Journal Article

This study presents a fully powered RCT testing the effectiveness and acceptability of two positive body image online media-based micro-interventions designed for young children. A total of 439 children aged 4-6 years were randomised into one of four... Read More about "My body is amazing from the bottom to the top" - An RCT study testing two positive body image media micro-interventions for young children aged 4-6 years.

Accepting your Body after Cancer (ABC), a group-based online intervention for women treated for breast cancer: Study protocol for a feasibility randomised controlled trial (2025)
Journal Article

Introduction Breast cancer is the most common cancer among women worldwide. While increasing numbers of women are living beyond breast cancer, treatment-related body image concerns are common and associated with adverse consequences. Nonetheless, rig... Read More about Accepting your Body after Cancer (ABC), a group-based online intervention for women treated for breast cancer: Study protocol for a feasibility randomised controlled trial.

Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study (2024)
Journal Article

ABSTRACT

Background: Oncoplastic breast conserving surgery (OPBCS) may be a better option than mastectomy, but high-quality comparative evidence is lacking. The ANTHEM study (ISRCTN18238549) aimed to explore clinical and patient-reported outcomes... Read More about Clinical and patient-reported outcomes in women offered oncoplastic breast conserving surgery as an alternative to mastectomy in the ANTHEM multicentre, prospective cohort study.

Evaluating the effectiveness and acceptability of two positive body image media micro-interventions among children aged 4–6 years old – a study protocol (2024)
Journal Article

Background: Children’s online media perpetuates appearance idealised images and can negatively impact the way children feel about their own and other people’s bodies (e.g., weight bias) at a young age. The development and evaluation of body image int... Read More about Evaluating the effectiveness and acceptability of two positive body image media micro-interventions among children aged 4–6 years old – a study protocol.

Understanding the emergency medical service response to patients who are at imminent risk of out-of-hospital cardiac arrest (2024)
Journal Article

Study Aim: To understand the survival and emergency medical service call triage and response to patients who suffer an out-of-hospital cardiac arrest after the emergency medical service call is connected.
Methods: A descriptive retrospective data a... Read More about Understanding the emergency medical service response to patients who are at imminent risk of out-of-hospital cardiac arrest.

Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study (2024)
Journal Article

Introduction
Over half of patients who spend >48 hours in the intensive care unit (ICU) are fed via a nasogastric (NG) tube. Current guidance recommends continuous delivery of feed throughout the day and night. Emerging evidence from healthy human s... Read More about Does intermittent nutrition enterally normalise hormonal and metabolic responses to feeding in critically ill adults? A protocol for the dine-normal proof-of-concept randomised parallel group study.

The lycra arm sleeve for treatment of glenohumeral subluxation in people with sub-acute stroke: A randomised controlled (RC) feasibility study (2024)
Journal Article

Background: A Lycra arm sleeve has the potential to reduce glenohumeral subluxation (GHS) in people with stroke (PwS). Aims were 1) to provide feasibility data to inform a future fully powered randomised controlled trial 2) to understand whether pati... Read More about The lycra arm sleeve for treatment of glenohumeral subluxation in people with sub-acute stroke: A randomised controlled (RC) feasibility study.