All Outputs (195)

A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder (2021)
Journal Article

Introduction: Neoadjuvant cisplatin-based combination chemotherapy improves survival in muscle-invasive bladder cancer. However, response rates and survival remain suboptimal. We evaluated the efficacy, safety, and tolerability of cisplatin plus caba... Read More about A single arm phase II trial of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle invasive transitional cell carcinoma of the urinary bladder.

St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up (2021)
Journal Article

Purpose: The peri-operative and short-term benefits of unicompartmental knee arthroplasty (UKA) are well supported in the literature. However, there remains concern regarding the higher revision rate when compared with total knee replacement. This ma... Read More about St Georg Sled medial unicompartmental arthroplasty: survivorship analysis and function at 20years follow up.

Differential expression of the BCAT isoforms between breast cancer subtypes (2020)
Journal Article

© 2020, The Author(s). Background: Biological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have distinct locoregional patterns. This is related to metabolic phenotype, where... Read More about Differential expression of the BCAT isoforms between breast cancer subtypes.

Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients (2020)
Journal Article

Insulin-like growth factor binding protein 3 (IGFBP-3) plays a key role in breast cancer progression and was recently shown to bind to the chaperone protein glucose-regulated protein 78 (GRP78); however, the clinical significance of this association... Read More about Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients.

Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study (2020)
Journal Article

Antibiotic resistance is an unprecedented threat to modern medicine. The analysis of volatile organic compounds (VOCs) from bacteria potentially offers a rapid way to determine antibiotic susceptibility in bacteria. This study aimed to find the optim... Read More about Towards the identification of antibiotic-resistant bacteria causing urinary tract infections using volatile organic compounds analysis—a pilot study.

‘Everybody’s Different: The Appearance Game’. A randomised controlled trial evaluating an appearance-related board game intervention with children aged 9-11 years (2020)
Journal Article

This study evaluated the effectiveness of an educational board game aimed at increasing knowledge of appearance-related issues, positive body image, media literacy, and acceptance of appearance diversity with British school children. Two hundred and... Read More about ‘Everybody’s Different: The Appearance Game’. A randomised controlled trial evaluating an appearance-related board game intervention with children aged 9-11 years.

Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Older adults undergoing vascular surgery are particularly vulnerable to adverse outcomes by virtue of their vascular risk factors and medical comorbidities. This study aimed to determine the i... Read More about Daily medical liaison is associated with reduced length of stay and complications in selected patients admitted to a regional vascular surgery service.

How many words make a sample? Determining the minimum number of word tokens needed in connected speech samples for child speech assessment (2020)
Journal Article

Connected speech (CS) is an important component of child speech assessment in both clinical practice and research. There is debate in the literature regarding what size sample of CS is required to facilitate reliable measures of speech output. The ai... Read More about How many words make a sample? Determining the minimum number of word tokens needed in connected speech samples for child speech assessment.

Parent-reported socioemotional and cognitive development in children with a cleft lip and/or palate at 18 months: Findings from a UK birth cohort (2020)
Journal Article

Background: One of the most common congenital conditions in the world, cleft lip and/or palate (CL/P) has been shown to potentially impact long-term physical and developmental outcomes in affected children. However, little is known about the factors... Read More about Parent-reported socioemotional and cognitive development in children with a cleft lip and/or palate at 18 months: Findings from a UK birth cohort.

The development and validation of the Threat of Dementia Scale (2020)
Journal Article

Dementia represents a substantial threat to the self. However, to date, there is no reliable way to measure how threatened people feel by dementia. This article reports on two online studies. In Study 1, 248 participants rated statements about dement... Read More about The development and validation of the Threat of Dementia Scale.

Factors associated with advanced colorectal cancer differ between young and older adults in England: A population-based cohort study (2020)
Journal Article

Aim: Advanced stage presentation of colorectal cancer is associated with poorer survival outcomes, particularly among young adults. This study aimed to determine whether demographic risk factors for advanced stage presentation differed between young... Read More about Factors associated with advanced colorectal cancer differ between young and older adults in England: A population-based cohort study.

Illicit drug contamination of the Bristol Pound local currency (2020)
Journal Article

Reports have shown the prevalence of the contamination of banknotes with a number of different drugs. These studies have focused on investigating drug contamination levels on currency which is either nationally or even international distributed. To p... Read More about Illicit drug contamination of the Bristol Pound local currency.

Pathological response rates and quality of life outcomes of neoadjuvant cabazitaxel and cisplatin chemotherapy for muscle-invasive transitional cell carcinoma of the urinary bladder (2020)
Journal Article

Ignorance is not bliss: A UK study of sexual and domestic abuse awareness on campus, and correlations with confidence and positive action in a bystander program (2020)
Journal Article

This article reports on a U.K. research study encompassing two surveys which used evidence-based scales of awareness, confidence to intervene, and intervention opportunities and action regarding sexual and domestic abuse on campus. They were sent to... Read More about Ignorance is not bliss: A UK study of sexual and domestic abuse awareness on campus, and correlations with confidence and positive action in a bystander program.

Manometry performed at indwelling pleural catheter insertion to predict unexpandable lung (2020)
Journal Article

Background: The finding of unexpandable lung (UL) at an early timepoint is of increasing importance in guiding treatment decisions in patients with malignant pleural effusion (MPE). Pleural manometry is the most common technique to delineate UL, howe... Read More about Manometry performed at indwelling pleural catheter insertion to predict unexpandable lung.

Demographic trends in the incidence of young-onset colorectal cancer: A population-based study (2020)
Journal Article

Background: Evidence is emerging that the incidence of colorectal cancer is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. Methods: A population-based cohort study was... Read More about Demographic trends in the incidence of young-onset colorectal cancer: A population-based study.

Internet-delivered attentional bias modification training (iABMT) for the management of chronic musculoskeletal pain: A protocol for a randomised controlled trial (2020)
Journal Article

Introduction Chronic musculoskeletal pain is a complex medical condition that can significantly impact quality of life. Patients with chronic pain demonstrate attentional biases towards pain-related information. The therapeutic benefits of modifying... Read More about Internet-delivered attentional bias modification training (iABMT) for the management of chronic musculoskeletal pain: A protocol for a randomised controlled trial.

The Pre-BRA (pre-pectoral Breast Reconstruction EvAluation) feasibility study: protocol for a mixed-methods IDEAL 2a/2b prospective cohort study to determine the safety and effectiveness of prepectoral implant-based breast reconstruction (2020)
Journal Article

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. INTRODUCTION: Implant-based breast reconstruction is the most commonly performed reconstructive technique worldwide. Subpectoral reconstruction with mesh is the... Read More about The Pre-BRA (pre-pectoral Breast Reconstruction EvAluation) feasibility study: protocol for a mixed-methods IDEAL 2a/2b prospective cohort study to determine the safety and effectiveness of prepectoral implant-based breast reconstruction.

PEGASUS: the Design of an Intervention to Facilitate Shared Decision-making in Breast Reconstruction (2020)
Journal Article

© 2020, The Author(s). Studies have found varying levels of satisfaction after breast reconstruction surgery with a substantial group of patients reporting some level of regret about their decision. The variable outcomes reported by women undergoing... Read More about PEGASUS: the Design of an Intervention to Facilitate Shared Decision-making in Breast Reconstruction.

Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches (2019)
Journal Article

© 2019 H. P. Ellis et al. Glioblastoma is the most common primary adult brain tumour, and despite optimal treatment, the median survival is 12-15 months. Patients with matched recurrent glioblastomas were investigated to try to find actionable mutati... Read More about Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches.