All Outputs (3)

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome (2024)
Journal Article

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po... Read More about IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

Understanding the chemotherapy-induced bystander effect; an evaluation of the role of cytokine storm in an in-vitro model of the human bone marrow (2024)
Thesis

The phenomenon of donor cell leukaemia (DCL) occurs following haematopoietic stem cell transplantation (HSCT), but its aetiology is currently unknown. Previous work within the research group identified a chemotherapy-induced bystander effect (CIBE) i... Read More about Understanding the chemotherapy-induced bystander effect; an evaluation of the role of cytokine storm in an in-vitro model of the human bone marrow.

Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow (2023)
Journal Article

Donor cell leukaemia (DCL) is a complication of haematopoietic stem cell transplantation where donated cells become malignant within the patient's bone marrow. As DCL predominates as acute myeloid leukaemia, we hypothesized that the cytokine storm fo... Read More about Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow.