All Outputs (4)

Myosin Va transports dense core secretory vesicles in pancreatic MIN6 β-cells (2005)
Journal Article
Varadi, A., Tsuboi, T., & Rutter, G. A. (2005). Myosin Va transports dense core secretory vesicles in pancreatic MIN6 β-cells. Molecular Biology of the Cell, 16(6), 2670-2680. https://doi.org/10.1091/mbc.E04-11-1001

The role of unconventional myosins in neuroendocrine cells is not fully understood, with involvement suggested in the movement of both secretory vesicles and mitochondria. Here, we demonstrate colocalization of myosin Va (MyoVa) with insulin in pancr... Read More about Myosin Va transports dense core secretory vesicles in pancreatic MIN6 β-cells.

Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1 (2004)
Journal Article
Varadi, A., Johnson-Cadwell, L. I., Cirulli, V., Yoon, Y., Allan, V. J., & Rutter, G. A. (2004). Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. Journal of Cell Science, 117(19), 4389-4400. https://doi.org/10.1242/jcs.01299

While the subcellular organisation of mitochondria is likely to influence many aspects of cell physiology, its molecular control is poorly understood. Here, we have investigated the role of the retrograde motor protein complex, dynein-dynactin, in mi... Read More about Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1.

Involvement of conventional kinesin in glucose-stimulate secretory granule movements and exocytosis in clonal pancreatic β-cells (2002)
Journal Article
Varadi, A., Ainscow, E., Allan, V. J., & Rutter, G. A. (2002). Involvement of conventional kinesin in glucose-stimulate secretory granule movements and exocytosis in clonal pancreatic β-cells. Journal of Cell Science, 115(21), 4177-4189. https://doi.org/10.1242/jcs.00083

Recruitment of secretory vesicles to the cell surface is essential for the sustained secretion of insulin in response to glucose. At present, the molecular motors involved in this movement, and the mechanisms whereby they may be regulated, are undefi... Read More about Involvement of conventional kinesin in glucose-stimulate secretory granule movements and exocytosis in clonal pancreatic β-cells.

Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 cells using recombinant targeted cameleons: Roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors (2002)
Journal Article
Varadi, A., & Rutter, G. A. (2002). Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 cells using recombinant targeted cameleons: Roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors. Diabetes, 51(S1), 190-201. https://doi.org/10.2337/diabetes.51.2007.S190

The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca2+ concentrations ([Ca2+]cyt) and hence in insulin secretion from pancreatic β-cells. However, the molecular mechanisms involved in both the uptake and release of Ca... Read More about Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 cells using recombinant targeted cameleons: Roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors.