Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

Crome, Laura; Nyirenda, Maggie; Sajjanhar, Tina; Leighton, Shona; McLellan, Shona; Bell, Claire; Mulligan, Joanne; Rounding, Sarah; Iqbal, Yasser; Ensom, Ruth; Bayreuther, Jane; Cathie, Katrina; Barling, Jason M.; Gormley, Stuart; Morcombe, Julie; Evans, Jayne; Ramlakhan, Shammi; Burke, Derek; Danziger, Donna; Wilson, Jill L.; Potier de la Morandiere, Katherine; Thomas, Rhys; Skene, Imogen; Parikh, Ami; Grahamslaw, Julia; O'Neill, Thomas; Browning, Jen; MacLeod, Stewart; Choudhery, Vince; Neil, Ashleigh; Small, Jennie; Mackle, Daisy; Appelboam, Andy; Howells, Rachel J.; Millar, Muriel; Dalzell, Elizabeth; Maney, Julie Ann; Walton, Emily; Ramsay, Rebecca; Bevan, Catherine; Finucane, Sonya; Gough, Christopher; Hay, Felix; Roland, Damian; Mollard, Helen; Downes, Alice J.; Cotton, Hannah; Riozzi, Paul; Helyer, Sinead; Cantle, Fleur; Sutherland, Emer; Armstrong, Sonia; Kumar, Ramesh; Scott, Alex; Devine, Kirsty; Bell, Kathryn; Anderson, Mark; Sheedy, Alyce B.; Laque, Martin; Criddle, John; Unsworth, Vanessa; Smith, Coral J.; Sunley, Rachel C.; Robinson, Gisela; Faza, Hani; Prudhoe, Sarah; Corrigan, Paul P.; Mullen, Niall; Hacking, Jo; Ramsey, Natasha; Ross, James; Bingham, Tracey; Smith, Alice; Moulsdale, Phoebe; Lavigne-Smith, Holly R.; Fernandez, Daphin; Hopkins, Juliet; Rogers, Louise; Hartshorn, Stuart; Hughes, Sharon; Lewis, Lucy; Buchanan, Mark; Greenwood-Bibby, Rachel; Hardwick, Susie; Pereira, Matthew; Appleton, Richard E.; Evans, Vicki; Iyer, Anand; Tate, Paul; Potter, Sarah; Lee, Elizabeth D.; Noblet, Joanne; Roper, Louise; Woolfall, Kerry; Hickey, Helen; Humphreys, Amy; Messahel, Shrouk; Gamble, Carrol; Rainford, Naomi E.A.; Lyttle, Mark D.

doi:10.1016/S0140-6736(19)30724-X

All Outputs (2)

Effect of Amoxicillin dose and treatment duration on the need for antibiotic re-treatment in children with Community-Acquired Pneumonia: The CAP-IT randomized clinical trial (2021)
Journal Article

Importance: The optimal dose and duration of oral amoxicillin for children with community-acquired pneumonia (CAP) are unclear. Objective: To determine whether lower-dose amoxicillin is noninferior to higher dose and whether 3-day treatment is noninf... Read More about Effect of Amoxicillin dose and treatment duration on the need for antibiotic re-treatment in children with Community-Acquired Pneumonia: The CAP-IT randomized clinical trial.

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial (2019)
Journal Article

Background
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in the UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This... Read More about Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.