The efficacy and safety of PSD503 (phenylephrine 20%, w/w) for topical application in women with stress urinary incontinence. A phase II, multicentre, double-blind, placebo controlled, 2-way cross over study.

Robinson, Dudley; Abrams, Paul; Cardozo, Linda; Ellis-Jones, Julie; Heath, Pat; Wyllie, Mike

Abstract

This is the first proof of concept study to demonstrate that a topical α adrenergic agonist gel is rapidly and consistently absorbed vaginally and may have a role in the management of female SUI. However, since recruitment was difficult this may indicate that whilst objectively effective, acceptability in clinical practice may be poor.

Citation

Robinson, D., Abrams, P., Cardozo, L., Ellis-Jones, J., Heath, P., & Wyllie, M. (2011). The efficacy and safety of PSD503 (phenylephrine 20%, w/w) for topical application in women with stress urinary incontinence. A phase II, multicentre, double-blind, placebo controlled, 2-way cross over study. European Journal of Obstetrics and Gynecology and Reproductive Biology, 159(2), 457-460

• Journal Article Type: Article
• Publication Date: Dec 1, 2011
• Journal: European journal of obstetrics, gynecology, and reproductive biology
• Print ISSN: 0301-2115
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 159
• Issue: 2
• Pages: 457-460
• Keywords: stress urinary incontinence
• Public URL: https://uwe-repository.worktribe.com/output/957321