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Low dose ionizing radiation produces too few reactive oxygen species to directly affect antioxidant concentrations in cells

Willey, Neil; Smith, J. T.; Hancock, John T.

Authors

Neil Willey Neil.Willey@uwe.ac.uk
Professor in Env Plant Physiology

J. T. Smith



Abstract

It has been hypothesized that radiation-induced oxidative stress is the mechanism for a wide range of negative impacts on biota living in radioactively contaminated areas around Chernobyl. The present study tests this hypothesis mechanistically, for the first time, by modelling the impacts of radiolysis products within the cell resulting from radiations (low linear energy transfer β and γ), and dose rates appropriate to current contamination types and densities in the Chernobyl exclusion zone and at Fukushima. At 417 μGy h-1 (illustrative of the most contaminated areas at Chernobyl), generation of radiolysis products did not significantly impact cellular concentrations of reactive oxygen species, or cellular redox potential. This study does not support the hypothesis that direct oxidizing stress is a mechanism for damage to organisms exposed to chronic radiation at dose rates typical of contaminated environments. This journal is © 2012 The Royal Society.

Citation

Hancock, J. T., Willey, N. J., Smith, J. T., Willey, N., & Hancock, J. T. (2012). Low dose ionizing radiation produces too few reactive oxygen species to directly affect antioxidant concentrations in cells. Biology Letters, 8(4), 594-597. https://doi.org/10.1098/rsbl.2012.0150

Journal Article Type Article
Publication Date Aug 23, 2012
Journal Biology Letters
Electronic ISSN 1744-957X
Publisher Royal Society, The
Peer Reviewed Peer Reviewed
Volume 8
Issue 4
Pages 594-597
DOI https://doi.org/10.1098/rsbl.2012.0150
Keywords Chernobyl, Fukushima, radiation, oxidative stress, biota
cell
Public URL https://uwe-repository.worktribe.com/output/948589
Publisher URL http://dx.doi.org/10.1098/rsbl.2012.0150
Additional Information Additional Information : Published online before print: 11th April, 2012