Clinical evidence of parietal cortex dysfunction and correlation with extent of allodynia in Complex Regional Pain Syndrome (CRPS) Type 1

Cohen, Helen; McCabe, Candy; Harris, Nigel; Hall, Jane; Lewis, Jenny; Blake, David

Abstract

- What's already known about this topic? There is increasing neuroimaging evidence of parietal lobe involvement in CRPS. Severe tactile allodynia and unusual symptoms such as body dysmorphia and finger agnosia have also been documented. - What does this study add?
Clinical evidence was found for parietal lobe dysfunction in CRPS. Cortical network dysfunction in CRPS may involve parietal areas, and could provide a rationale explanation for otherwise unusual symptoms and signs. The extent of tactile allodynia correlated with the severity of parietal dysfunction, suggesting a role for maladaptive neuroplasticity.

• Journal Article Type: Article
• Publication Date: Aug 2, 2012
• Deposit Date: Aug 6, 2012
• Journal: European Journal of Pain
• Print ISSN: 1090-3801
• Electronic ISSN: 1532-2149
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 4
• Pages: 527-538
• DOI: https://doi.org/10.1002/j.1532-2149.2012.00213.x
• Keywords: parietal cortex, Complex Regional Pain Syndrome, allodynia, allochiria, neurogenic inflammation
• Public URL: https://uwe-repository.worktribe.com/output/944907
• Publisher URL: http://dx.doi.org/10.1002/j.1532-2149.2012.00213.x
• Contract Date: Nov 15, 2016