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Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: A prospective observational study protocol

Pollock, J.; Bonfield, M.; Cramp, F.; Bonfield, Michelle; Cramp, Fiona A; Pollock, Jon

Authors

J. Pollock

M. Bonfield

F. Cramp

Michelle Bonfield michelle.bonfield@uwe.ac.uk

Fiona Cramp Fiona.Cramp@uwe.ac.uk
Professor in Long Term Conditions

Jon Pollock Jon.Pollock@uwe.ac.uk
Associate Professor in Epidemiology



Abstract

© 2016 The Author(s) Background: Reasons for the variation in response of deep vein thrombosis (DVT) to anticoagulation treatmenot known. Some patients develop complications such as post-thrombotic syndrome or recurrent DVT but othmake a full recovery. The aim of the study is to identify the level of variation in response to anticoagulation treatment and provide more precise and quantitative disease characterisation in response to treatment. Methods: A prospective observational study using duplex ultrasound to examine changes in thrombus characterisation, evolution and resolution over a 2 year period in patients with a confirmed DVT. Logistic regreanalysis will be used to seek associations between characteristics present at baseline and the outcomes of DVresolution, recurrence and the development of post-thrombotic syndrome (PTS). Discussion: This research into the response to treatment of lower limb DVT and predictive factors for DVT resolution, recurrence and PTS could inform a more tailored approach to anticoagulation therapy for the futurmanagement of DVT. UKCRN ID: 16016. Registered on 20 January 2014.

Citation

Cramp, F., Bonfield, M., Pollock, J., Bonfield, M., Cramp, F. A., & Pollock, J. (2016). Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: A prospective observational study protocol. BMC Hematology, 16(1), https://doi.org/10.1186/s12878-016-0063-7

Journal Article Type Article
Acceptance Date Sep 5, 2016
Publication Date Jan 1, 2016
Journal BMC Hematology
Electronic ISSN 2052-1839
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 16
Issue 1
DOI https://doi.org/10.1186/s12878-016-0063-7
Keywords deep vein thrombosis, post-thrombotic syndrome, resolution, recurrence, anticoagulation
Public URL https://uwe-repository.worktribe.com/output/917143
Publisher URL http://dx.doi.org/10.1186/s12878-016-0063-7

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