Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation

Hancock, John T

doi:10.3389/fpls.2017.00189

Harnessing evolutionary toxins for signaling: Reactive oxygen species, nitric oxide and hydrogen sulfide in plant cell regulation

Hancock, John T

Authors

John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling

Abstract

© 2017 Hancock. During the early periods of evolution, as well as in niche environments today, organisms have had to learn to tolerate the presence of many reactive compounds, such as reactive oxygen species, nitric oxide, and hydrogen sulfide. It is now known that such compounds are instrumental in the signaling processes in plant cells. There are enzymes which can make them, while downstream of their signaling pathways are coming to light. These include the production of cGMP, the activation of MAP kinases and transcription factors, and the modification of thiol groups on many proteins. However, organisms have also had to tolerate other reactive compounds such as ammonia, methane, and hydrogen gas, and these too are being found to have profound effects on signaling in cells. Before a holistic view of how such signaling works, the full effects and interactions of all such reactive compounds needs to be embraced. A full understanding will be beneficial to both agriculture and future therapeutic strategies.

Journal Article Type	Article
Acceptance Date	Jan 30, 2017
Publication Date	Feb 10, 2017
Deposit Date	Feb 2, 2017
Publicly Available Date	Feb 2, 2017
Journal	Frontiers in Plant Science
Print ISSN	1664-462X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	8
Pages	189
DOI	https://doi.org/10.3389/fpls.2017.00189
Keywords	cell signalling, hydrogen peroxide, hydrogen gas, hydrogen sulfide, nitric oxide
Public URL	https://uwe-repository.worktribe.com/output/898508
Publisher URL	http://journal.frontiersin.org/article/10.3389/fpls.2017.00189/abstract
Contract Date	Feb 2, 2017