Skip to main content

Research Repository

Advanced Search

International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials

De Wit, Maarten; Shea, Judy A.; Grieb, Suzanne Dolwick; Elmamoun, Musaab; Callis Duffin, Kristina; Christensen, Robin; de Witt, Maarten; Shea, Judy; Orbai, Ana Maria; Elmamoum, Mussab; Mease, Philip; Duffin, Kristina; Gossec, Laure; Christensent, Robin; Leung, Ying Ying; Tillett, William; Campbell, Willemina; Coates, Laura; Grieg, Suzanne; Dures, Emma; Eder, Lihi; Fitzgerald, Oliver; Gladman, Dafna; Goel, Niti; Hewlett, Sarah; Hoejgaard, Pil; Kalyoncu, Umut; Lindsay, Chris; McHugh, Neil; Shea, Bev; Steinkoenig, Ingrid; Strand, Vibeke; Ogdie, Alexis

International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials Thumbnail


Authors

Maarten De Wit

Judy A. Shea

Suzanne Dolwick Grieb

Musaab Elmamoun

Kristina Callis Duffin

Robin Christensen

Maarten de Witt

Judy Shea

Ana Maria Orbai

Mussab Elmamoum

Philip Mease

Kristina Duffin

Laure Gossec

Robin Christensent

Ying Ying Leung

William Tillett

Willemina Campbell

Laura Coates

Suzanne Grieg

Emma Dures Emma2.Dures@uwe.ac.uk
Professor in Rheumatology and Self-management

Lihi Eder

Oliver Fitzgerald

Dafna Gladman

Niti Goel

Pil Hoejgaard

Umut Kalyoncu

Chris Lindsay

Neil McHugh

Bev Shea

Ingrid Steinkoenig

Vibeke Strand

Alexis Ogdie



Abstract

© 2017 Published by the BMJ Publishing Group Limited. Objective To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities. Methods We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-To-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016. All phases were performed in collaboration with patient research partners. Results We identified 39 unique domains through the SLR (24 domains) and international focus groups (34 domains). 50 patients and 75 physicians rated domain importance. During the March 2016 consensus meeting, 12 patients and 12 physicians agreed on 10 candidate domains. Then, 49 patients and 71 physicians rated these domains' importance. Five were important to >70% of both groups: musculoskeletal disease activity, skin disease activity, structural damage, pain and physical function. Fatigue and participation were important to >70% of patients. Patient global and systemic inflammation were important to >70% of physicians. The updated PsA core domain set endorsed by 90% of OMERACT 2016 participants includes musculoskeletal disease activity, skin disease activity, pain, patient global, physical function, health-related quality of life, fatigue and systemic inflammation. Conclusions The updated PsA core domain set incorporates patients' and physicians' priorities and evolving PsA research. Next steps include identifying outcome measures that adequately assess these domains.

Citation

Christensen, R., Callis Duffin, K., Elmamoun, M., Grieb, S. D., Shea, J. A., De Wit, M., …Ogdie, A. (2017). International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials. Annals of the Rheumatic Diseases, 76(4), 673-680. https://doi.org/10.1136/annrheumdis-2016-210242

Journal Article Type Article
Acceptance Date Aug 21, 2016
Online Publication Date Sep 9, 2016
Publication Date Apr 1, 2017
Deposit Date Nov 11, 2016
Publicly Available Date Mar 28, 2024
Journal Annals of the Rheumatic Diseases
Print ISSN 0003-4967
Electronic ISSN 1468-2060
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 76
Issue 4
Pages 673-680
DOI https://doi.org/10.1136/annrheumdis-2016-210242
Keywords international, patient, physician, consensus, psoriatic, arthritis, clinical, trials
Public URL https://uwe-repository.worktribe.com/output/890109
Publisher URL http://dx.doi.org/10.1136/annrheumdis-2016-210242