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Priorities for nutrition research in pediatric critical care

Tume, Lyvonne N; Valla, Frederic V; Floh, Alejandro; Goday, Praveen; Jotterand Chaparro, Corrine; Larsen, Bodil; Lee, Jan Hau; Moreno, Yara; Patham, Nazima; Verbruggen, Sascha; Mehta, Nilesh

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Lyvonne N Tume

Frederic V Valla

Alejandro Floh

Praveen Goday

Corrine Jotterand Chaparro

Bodil Larsen

Jan Hau Lee

Yara Moreno

Nazima Patham

Sascha Verbruggen

Nilesh Mehta


Background: Widespread variation exists in pediatric critical care nutrition practices, largely because of the scarcity of evidence to guide best practice recommendations.

Objective: The objective of this paper was to develop a list of topics to be prioritized for nutrition research in pediatric critical care in the next 10 years.

Methods: A modified 3-round Delphi process was undertaken by a newly established multidisciplinary group comprising 11 international researchers in the field of pediatric critical care nutrition. Items were ranked on a 5-point Likert scale.

Results: Forty-five research topics (with a mean priority score >3(0-5) were identified within the following 10 domains: the pathophysiology and impact of malnutrition in critical illness; nutrition assessment: nutrition risk assessment and biomarkers; accurate assessment of energy requirements in all phases of critical illness; the role of protein intake; the role of pharmaco-nutrition; effective and safe delivery of enteral nutrition; enteral feeding intolerance: assessment and management; the role of parenteral nutrition; the impact of nutrition status and nutrition therapies on long-term patient outcomes; and nutrition therapies for specific populations. Ten top research topics (that received a mean score >4(0-5) were identified as the highest priority for research.

Conclusions: This paper has identified important consensus-derived priorities for clinical research in pediatric critical care nutrition. Future studies should determine topics that are a priority for patients and parents. Research funding should target these priority areas and promote an international collaborative approach to research in this field, with a focus on improving relevant patient outcomes.

Journal Article Type Article
Acceptance Date Dec 3, 2018
Online Publication Date Dec 26, 2018
Publication Date Sep 1, 2019
Deposit Date Dec 10, 2018
Publicly Available Date Dec 27, 2019
Journal Journal of Parenteral and Enteral Nutrition
Print ISSN 0148-6071
Electronic ISSN 1941-2444
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 43
Issue 7
Pages 853-862
Keywords research priorities, nutrition, child, critically ill
Public URL
Publisher URL
Additional Information Additional Information : This is the peer reviewed version of the following article: Tume, L. N. , Valla, F. V. , Floh, A. , Goday, P. , Jotterand Chaparro, C. , Larsen, B. , Lee, J. H. , Moreno, Y. , Patham, N. , Verbruggen, S. and Mehta, N. (2018) Priorities for nutrition research in pediatric critical care. Journal of Parenteral and Enteral Nutrition. ISSN 0148-6071, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Contract Date Dec 10, 2018


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