Edward Watts Carlton
Limit of detection of troponin discharge strategy versus usual care: Randomised controlled trial
Carlton, Edward Watts; Ingram, Jenny; Taylor, Hazel; Glynn, Joel; Kandiyali, Rebecca; Campbell, Sarah; Beasant, Lucy; Aziz, Shahid; Beresford, Peter; Kendall, Jason; Reuben, Adam; Smith, Jason E; Chapman, Rebecca; Creanor, Siobhan; Benger, Jonathan Richard
Authors
Jenny Ingram
Hazel Taylor
Joel Glynn
Rebecca Kandiyali
Sarah Campbell
Lucy Beasant
Shahid Aziz
Peter Beresford
Jason Kendall
Adam Reuben
Jason E Smith
Rebecca Chapman
Siobhan Creanor
Jonathan Richard Benger
Abstract
Introduction The clinical effectiveness of a a € rule-out' acute coronary syndrome (ACS) strategy for emergency department patients with chest pain, incorporating a single undetectable high-sensitivity cardiac troponin (hs-cTn) taken at presentation, together with a non-ischaemic ECG, remains unknown. Methods A randomised controlled trial, across eight hospitals in the UK, aimed to establish the clinical effectiveness of an undetectable hs-cTn and ECG (limit of detection and ECG discharge (LoDED)) discharge strategy. Eligible adult patients presented with chest pain; the treating clinician intended to perform investigations to rule out an ACS; the initial ECG was non-ischaemic; and peak symptoms occurred 40% of patients with chest pain. Clinical effectiveness is variable when compared with existing rule-out strategies and influenced by wider system factors. Trial registration number ISRCTN86184521.
Citation
Carlton, E. W., Ingram, J., Taylor, H., Glynn, J., Kandiyali, R., Campbell, S., …Benger, J. R. (2020). Limit of detection of troponin discharge strategy versus usual care: Randomised controlled trial. Heart, 106(20), 1586-1594. https://doi.org/10.1136/heartjnl-2020-316692
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 30, 2020 |
Online Publication Date | May 5, 2020 |
Publication Date | Sep 25, 2020 |
Deposit Date | Nov 2, 2021 |
Publicly Available Date | Mar 28, 2024 |
Journal | Heart |
Print ISSN | 1355-6037 |
Electronic ISSN | 1468-201X |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 106 |
Issue | 20 |
Pages | 1586-1594 |
DOI | https://doi.org/10.1136/heartjnl-2020-316692 |
Keywords | Cardiology and Cardiovascular Medicine |
Public URL | https://uwe-repository.worktribe.com/output/8044573 |
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Limit of detection of troponin discharge strategy versus usual care: randomised controlled trial
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Licence
http://creativecommons.org/licenses/by-nc/4.0/
Publisher Licence URL
http://creativecommons.org/licenses/by-nc/4.0/
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