Alex Yue Alex.Yue@uwe.ac.uk
Senior Lecturer in Bioinstrumentation and Sensor Interfacing
Alex Yue Alex.Yue@uwe.ac.uk
Senior Lecturer in Bioinstrumentation and Sensor Interfacing
Emmanuel M. Drakakisa
Athanasios Mantalaris
Anthony Cass
Cellular behavior is influenced by micro-concentration gradients existing in their immediate spatio-environment. A practical real-time measurement system, composed of miniaturized long-lasting sensors placed within a two-dimensional bioreactor and a 32-channel data acquisition system for ammonia, is presented in this paper aiming to generate the spatio-temporal ammonia concentration profiles for the whole culture process. Our results demonstrate the feasibility of the system and its applicability in elucidating the cell growth micro-environment within a bioreactor, which can potentially facilitate the intelligent control of ammonia levels in cell culture systems. The presented system is flexible enough to interface other sensors for generating their spatio-temporal profiles of the sensed cell culture
parameters.
Journal Article Type | Article |
---|---|
Online Publication Date | Jun 10, 2010 |
Publication Date | Nov 1, 2010 |
Deposit Date | May 7, 2021 |
Print ISSN | 1536-6367 |
Electronic ISSN | 1536-6359 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 43 |
Issue | 9 |
Pages | 1207-1216 |
DOI | https://doi.org/10.1016/j.measurement.2010.05.012 |
Public URL | https://uwe-repository.worktribe.com/output/5667469 |
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