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The role of the gut microbiota in health, diet, and disease with a focus on obesity

Ma, Zheng Feei; Lee, Yeong Yeh

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Authors

Yeong Yeh Lee



Abstract

The gut microbiota has been increasingly recognised as a critical determinant of human health, influencing a wide range of physiological processes. A healthy gut microbiota is essential for maintaining metabolic, immune, and gastrointestinal homeostasis, contributing to overall well-being. Alterations in its composition and functionality, often referred to as microbial dysbiosis, are strongly associated with the development of gut-related and systemic diseases. The gut microbiota synthesises several components and interacts with epithelial cell receptors, influencing processes that extend beyond nutritional status to the pathogenesis of diseases such as obesity, which extend beyond their known contribution to nutritional status. Therefore, this state-of-the-art review synthesises findings from recent studies on the composition, functions, and influencing factors of the gut microbiota, with a focus on its role in obesity. A systematic search of peer-reviewed literature was conducted to ensure comprehensive coverage, while expert insights are incorporated to discuss emerging research directions and future perspectives in the field.

Journal Article Type Article
Acceptance Date Jan 27, 2025
Online Publication Date Feb 4, 2025
Publication Date Feb 4, 2025
Deposit Date Feb 15, 2025
Publicly Available Date Feb 26, 2025
Journal Foods
Electronic ISSN 2304-8158
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 14
Issue 3
Article Number 492
DOI https://doi.org/10.3390/foods14030492
Public URL https://uwe-repository.worktribe.com/output/13760615

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