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Proton pump inhibitor omeprazole alters the spiking characteristics of proteinoids

Mougkogiannis, Panagiotis; Adamatzky, Andrew

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Authors

Panagiotis Mougkogiannis



Abstract

This study reveals the significant effect of the proton pump inhibitor omeprazole on the spiking behavior of proteinoids, leading to a transformative shift in the field of unconventional computing. Through the application of different concentrations of omeprazole, we see a notable modification in the spiking characteristics of proteinoids, including significant alterations in amplitude, frequency, and temporal patterns. By using Boolean logic techniques, we analyze the complex dynamics of the proteinoid-omeprazole system, revealing underlying patterns and connections that question our understanding of biological computing. Our research reveals the unexplored potential of proteinoids as a foundation for unconventional computing. Moreover, our research indicates that the electrical spiking observed in proteinoids may be linked to the movement of protons. This discovery offers new insights into the fundamental mechanisms governing the spiking activity of proteinoids, presenting promising opportunities for future research in this area. Additionally, it opens up possibilities of developing new computational models that exploit the inherent nonlinearity and complexity of biological systems. By combining the effects of omeprazole-induced spikes with Boolean logic, a wide range of opportunities arise for information processing, pattern identification, and problem-solving. This pushes the limits of what can be achieved with bioelectronics.

Journal Article Type Article
Acceptance Date Jan 21, 2025
Online Publication Date Jan 27, 2025
Publication Date Feb 11, 2025
Deposit Date Jan 28, 2025
Publicly Available Date Jan 28, 2025
Electronic ISSN 2470-1343
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 10
Issue 5
Pages 5016–5035
DOI https://doi.org/10.1021/acsomega.4c10790
Public URL https://uwe-repository.worktribe.com/output/13652359

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