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Developing a core outcome set for foot and ankle disorders in rheumatic and musculoskeletal diseases: A scoping review and report from the OMERACT 2022 foot and ankle special interest group session

Chapman, Lara S; Jones, Jennifer; Redmond, Anthony C; Flurey, Caroline A; Richards, Pamela; Hofstetter, Catherine; Smith, Toby O; Arnold, John B; Hannan, Marian T; Maxwell, Lara J; Menz, Hylton B; Shea, Beverley; Golightly, Yvonne M; Tugwell, Peter; Beaton, Dorcas; Conaghan, Philip G; Helliwell, Philip S; Siddle, Heidi J

Developing a core outcome set for foot and ankle disorders in rheumatic and musculoskeletal diseases: A scoping review and report from the OMERACT 2022 foot and ankle special interest group session Thumbnail


Authors

Lara S Chapman

Jennifer Jones

Anthony C Redmond

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Caroline Flurey Caroline2.Flurey@uwe.ac.uk
Associate Professor in Men's Health and Long-term Conditions

Pamela Richards

Catherine Hofstetter

Toby O Smith

John B Arnold

Marian T Hannan

Lara J Maxwell

Hylton B Menz

Beverley Shea

Yvonne M Golightly

Peter Tugwell

Dorcas Beaton

Philip G Conaghan

Philip S Helliwell

Heidi J Siddle



Abstract

Objectives: Foot and ankle involvement is common in rheumatic and musculoskeletal diseases, yet high-quality evidence assessing the effectiveness of treatments for these disorders is lacking. The Outcome Measures in Rheumatology (OMERACT) Foot and Ankle Working Group is developing a core outcome set for use in clinical trials and longitudinal observational studies in this area. Methods: A scoping review was performed to identify outcome domains in the existing literature. Clinical trials and observational studies comparing pharmacological, conservative or surgical interventions involving adult participants with any foot or ankle disorder in the following rheumatic and musculoskeletal diseases (RMDs) were eligible for inclusion: rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthropathies, crystal arthropathies and connective tissue diseases. Outcome domains were categorised according to the OMERACT Filter 2.1. Results: Outcome domains were extracted from 150 eligible studies. Most studies included participants with foot/ankle OA (63% of studies) or foot/ankle involvement in RA (29% of studies). Foot/ankle pain was the outcome domain most commonly measured (78% of studies), being the most frequently specified outcome domain across all RMDs. There was considerable heterogeneity in the other outcome domains measured, across core areas of manifestations (signs, symptoms, biomarkers), life impact, and societal/resource use. The group's progress to date, including findings from the scoping review, was presented and discussed during a virtual OMERACT Special Interest Group (SIG) in October 2022. During this meeting, feedback was sought amongst delegates regarding the scope of the core outcome set, and feedback was received on the next steps of the project, including focus group and Delphi methods. Conclusion: Findings from the scoping review and feedback from the SIG will contribute to the development of a core outcome set for foot and ankle disorders in RMDs. The next steps are to determine which outcome domains are important to patients, followed by a Delphi exercise with key stakeholders to prioritise outcome domains.

Citation

Chapman, L. S., Jones, J., Redmond, A. C., Flurey, C. A., Richards, P., Hofstetter, C., …Siddle, H. J. (2023). Developing a core outcome set for foot and ankle disorders in rheumatic and musculoskeletal diseases: A scoping review and report from the OMERACT 2022 foot and ankle special interest group session. Seminars in Arthritis and Rheumatism, 61, Article 152210. https://doi.org/10.1016/j.semarthrit.2023.152210

Journal Article Type Article
Acceptance Date May 2, 2023
Online Publication Date May 4, 2023
Publication Date Aug 1, 2023
Deposit Date May 30, 2023
Publicly Available Date May 31, 2023
Journal Seminars in Arthritis and Rheumatism
Print ISSN 0049-0172
Electronic ISSN 1532-866X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 61
Article Number 152210
DOI https://doi.org/10.1016/j.semarthrit.2023.152210
Keywords Ankle, Scoping review, Outcome measures, Rheumatology, Foot, OMERACT
Public URL https://uwe-repository.worktribe.com/output/10823716
Publisher URL https://www.sciencedirect.com/science/article/pii/S0049017223000525?via%3Dihub

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