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Hydrogen peroxide and nitric oxide as signalling molecules in plants

Neill, Steven; Desikan, Radhika; Clarke, Andrew; Hurst, Roger D.; Hancock, John T.


Radhika Desikan

Andrew Clarke

Roger D. Hurst

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John Hancock
Professor in Cell Signalling


It is now clear that hydrogen peroxide (H2O2) and nitric oxide (NO) function as signalling molecules in plants. A wide range of abiotic and biotic stresses results in H2O2 generation, from a variety of sources. H2O2 is removed from cells via a number of antioxidant mechanisms, both enzymatic and non-enzymatic. Both biotic and abiotic stresses can induce NO synthesis, but the biosynthetic origins of NO in plants have not yet been resolved. Cellular responses to H2O2 and NO are complex, with considerable cross-talk between responses to several stimuli. In this review the potential roles of H2O2 and NO during various stresses and the signalling pathways they activate are discussed. Key signalling components that might provide targets for enhancing crop production are also identified.


Neill, S., Desikan, R., Clarke, A., Hurst, R. D., & Hancock, J. T. (2002). Hydrogen peroxide and nitric oxide as signalling molecules in plants. Journal of Experimental Botany, 53(372), 1237-1247

Journal Article Type Article
Publication Date May 15, 2002
Journal Journal of Experimental Botany
Print ISSN 0022-0957
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 53
Issue 372
Pages 1237-1247
Keywords abiotic and biotic stress, hydrogen peroxide, nitric oxide, signalling molecule
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