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Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite

Hancock, John T.; Salisbury, Vyv; Ovejero-Boglione, Maria Cristina; Cherry, Robert; Hoare, Catherine; Eisenthal, Robert; Harrison, Roger

Authors

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John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling

Vyv Salisbury

Maria Cristina Ovejero-Boglione

Robert Cherry

Catherine Hoare

Robert Eisenthal

Roger Harrison



Abstract

Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.

Journal Article Type Article
Publication Date Oct 1, 2002
Journal Antimicrobial Agents and Chemotherapy
Print ISSN 0066-4804
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 46
Issue 10
Pages 3308-3310
DOI https://doi.org/10.1128/AAC.46.10.3308-3310.2002
Public URL https://uwe-repository.worktribe.com/output/1076242
Publisher URL http://dx.doi.org/10.1128/AAC.46.10.3308-3310.2002