Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite

Hancock, John T.; Salisbury, Vyv; Ovejero-Boglione, Maria Cristina; Cherry, Robert; Hoare, Catherine; Eisenthal, Robert; Harrison, Roger

Abstract

Human and bovine milk inhibited the metabolic activity of Escherichia coli, as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.

Citation

Hancock, J. T., Salisbury, V., Ovejero-Boglione, M. C., Cherry, R., Hoare, C., Eisenthal, R., & Harrison, R. (2002). Antimicrobial properties of milk: Dependence on presence of xanthine oxidase and nitrite. Antimicrobial Agents and Chemotherapy, 46(10), 3308-3310. https://doi.org/10.1128/AAC.46.10.3308-3310.2002

• Journal Article Type: Article
• Publication Date: Oct 1, 2002
• Journal: Antimicrobial Agents and Chemotherapy
• Print ISSN: 0066-4804
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 46
• Issue: 10
• Pages: 3308-3310
• DOI: https://doi.org/10.1128/AAC.46.10.3308-3310.2002
• Public URL: https://uwe-repository.worktribe.com/output/1076242
• Publisher URL: http://dx.doi.org/10.1128/AAC.46.10.3308-3310.2002