Anthea Vreugdenhil
Obesity, abdominal obesity and Alzheimer disease
Vreugdenhil, Anthea; Razay, George; Wilcock, Gordon
Authors
George Razay
Gordon Wilcock
Abstract
Background/Aims: Obesity has a strong association with vascular and metabolic diseases, which have been linked with Alzheimer disease (AD). While recent studies have reported an association between mid-life obesity and dementia, the role of later-life obesity is less clear. This study investigated the relation between AD, obesity and abdominal obesity at later-life in a case-control study. Methods: Participants were 50 consecutive patients with probable AD from memory disorders clinics in Launceston, Australia, and Bristol, England, and 75 cognitively normal controls. Height and weight [from which body mass index (BMI) was calculated] and hip and waist circumferences (from which waist-hip ratio was calculated) were measured. Participants were classified according to their BMI as: underweight (BMI 0.9 (men) or >0.8 (women). Results: AD was associated with obesity [OR 9.5, 95% CI 2.4-37.3, p = 0.001], underweight (OR 5.4, CI 0.9-33.7, p = 0.07) and abdominal obesity (OR 2.5, CI 1.1-5.7, p = 0.027) using logistic regression analyses adjusted for age, sex and location. The inclusion of metabolic risk factors in the model increased the ORs for obesity (OR 12.6, CI 2.8-56.5, p = 0.001) and underweight (OR 7.9, CI 1.0-66.3, p = 0.056). Conclusion: AD may be associated with obesity, underweight and abdominal obesity at later life. Larger prospective studies are required to investigate this further. Copyright © 2006 S. Karger AG.
Journal Article Type | Article |
---|---|
Publication Date | Aug 1, 2006 |
Journal | Dementia and Geriatric Cognitive Disorders |
Print ISSN | 1420-8008 |
Publisher | Karger Publishers |
Peer Reviewed | Not Peer Reviewed |
Volume | 22 |
Issue | 2 |
Pages | 173-176 |
DOI | https://doi.org/10.1159/000094586 |
Keywords | obesity, abdominal obesity, Alzheimer disease |
Public URL | https://uwe-repository.worktribe.com/output/1042821 |
Publisher URL | http://dx.doi.org/10.1159/000094586 |
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