Outputs (1003)

An in vitro biofilm model of Staphylococcus aureus infection of bone (2019)
Journal Article

Chronic osteomyelitis is difficult to treat, with biofilm growth and the diffusion barrier to antibiotics presented by bone contributory factors. The aim of this study was to develop and evaluate an invitro model of osteomyelitis. A bioluminescent st... Read More about An in vitro biofilm model of Staphylococcus aureus infection of bone.

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa (2018)
Journal Article

© 2018, The Author(s). Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non-syndromic retinal disease. Here, we generate transcr... Read More about Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Effects of lipid composition on membrane permeation (2018)
Journal Article

© 2018 The Royal Society of Chemistry. Passive permeation through lipid membranes is an essential process in biology. In vivo membranes typically consist of mixtures of lamellar and nonlamellar lipids. Lamellar lipids are characterized by their tende... Read More about Effects of lipid composition on membrane permeation.

Basin-scale variability of microbial methanol uptake in the Atlantic Ocean (2018)
Journal Article

© 2018 Author(s). Methanol is a climate-active gas and the most abundant oxygenated volatile organic compound (OVOC) in the atmosphere and seawater. Marine methylotrophs are aerobic bacteria that utilise methanol from seawater as a source of carbon (... Read More about Basin-scale variability of microbial methanol uptake in the Atlantic Ocean.

Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds (2018)
Journal Article

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. It has become increasingly important to qualitatively and quantitatively assess the volatile metabolites in a range of bodily fluids for use in monitoring health. There has been relatively lit... Read More about Gas chromatography mass spectrometry (GC-MS) quantification of metabolites in stool using13 C labelled compounds.

Parameterization of a coarse-grained model of cholesterol with point-dipole electrostatics (2018)
Journal Article

© 2018, Springer Nature Switzerland AG. We present a new coarse-grained (CG) model of cholesterol (CHOL) for the electrostatic-based ELBA force field. A distinguishing feature of our CHOL model is that the electrostatics is modeled by an explicit poi... Read More about Parameterization of a coarse-grained model of cholesterol with point-dipole electrostatics.

Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important? (2018)
Journal Article

It is becoming accepted that treatment with hydrogen gas (H2) has profound and often beneficial effects on cells from both animals and plants. Future uses which have been suggested include for cancer treatment, for alleviating symptoms of Parkinson’s... Read More about Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?.

Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis (2018)
Journal Article

© 2018 The Authors. Published under the terms of the CC BY 4.0 license Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecu... Read More about Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis.

Microbial processing and production of aquatic fluorescent organic matter in a model freshwater system (2018)
Journal Article

© 2018 by the authors. Organic matter (OM) has an essential biogeochemical influence along the hydrological continuum and within aquatic ecosystems. Organic matter derived via microbial processes was investigated within a range of model freshwater sa... Read More about Microbial processing and production of aquatic fluorescent organic matter in a model freshwater system.

Climate change and insectivore ecology (2019)
Book Chapter

The impacts of climate change on natural populations are only beginning to be understood. Although some important changes are already occurring, in the future these are predicted to be more substantial and of greater ecological significance. Insects... Read More about Climate change and insectivore ecology.

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells (2019)
Journal Article

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia patients; ho... Read More about LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.

Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder (2019)
Journal Article

Micromotions are phasic contractions of the bladder wall. During urine storage, such phasic activity has little effect on intravesical pressure, however, changed motile activity may underlie urodynamic observations such as detrusor overactivity. The... Read More about Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder.

Altered VEGF splicing isoform balance in tumor endothelium involves activation of splicing factors Srpk1 and Srsf1 by the Wilms’ tumor suppressor Wt1 (2019)
Journal Article

Angiogenesis is one hallmark of cancer. Vascular endothelial growth factor (VEGF) is a known inducer of angiogenesis. Many patients benefit from antiangiogenic therapies, which however have limitations. Although VEGF is overexpressed in most tumors,... Read More about Altered VEGF splicing isoform balance in tumor endothelium involves activation of splicing factors Srpk1 and Srsf1 by the Wilms’ tumor suppressor Wt1.

Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK (2019)
Presentation / Conference Contribution

A point prevalence study (PPS) to determine the carriage rate of carbapenemase producing organisms (CPOs) was performed across 4 sites at Barts Health NHS Trust (BHT), encompassing 2.5 million patients across three London boroughs: Tower Hamlets, New... Read More about Point prevalence study determining the inpatient rate of carbapenemase-producing organisms at a large NHS trust in the UK.

Investigations into novel electrochemical technology for boar taint detection and vitamin analysis (2019)
Thesis

This thesis presents the evaluation of the novel electrochemical sensor and biosensor technology developed for the direct analysis of boar taint compounds in adipose tissue (European Patent 2966441). Gas chromatographic methods and extraction procedu... Read More about Investigations into novel electrochemical technology for boar taint detection and vitamin analysis.

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Retention characteristics of some antibiotic and anti-retroviral compounds in hydrophilic interaction chromatography using isocratic elution, and gradient elution with repeatable partial equilibration (2018)
Journal Article

© 2018 Elsevier B.V. The separation of some zwitterionic, basic and neutral antibiotic and antiretroviral compounds was studied using hydrophilic interaction chromatography (HILIC) on bare silica, bonded amide and urea superficially porous phases. T... Read More about Retention characteristics of some antibiotic and anti-retroviral compounds in hydrophilic interaction chromatography using isocratic elution, and gradient elution with repeatable partial equilibration.

Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease (2019)
Journal Article

© 2019 - IOS Press and the authors. All rights reserved. Background: Differential diagnosis of people presenting with mild cognitive impairment (MCI) that will progress to Alzheimer's disease (AD) remains clinically challenging. Current criteria used... Read More about Novel blood biomarkers that correlate with cognitive performance and hippocampal volumetry: Potential for early diagnosis of Alzheimer's disease.

Trace voltammetric determination of lead at a recycled battery carbon rod electrode (2019)
Journal Article

Carbon rod electrodes (CREs) were obtained from recycled zinc–carbon batteries and were used without further modification for the measurement of trace concentrations of lead (Pb). The electrochemical behavior of Pb at these electrodes in a variety of... Read More about Trace voltammetric determination of lead at a recycled battery carbon rod electrode.

BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells (2019)
Journal Article

To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in so... Read More about BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells.