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Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?

Hancock, John T.; Hancock, Thomas H.

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Authors

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John Hancock John.Hancock@uwe.ac.uk
Professor in Cell Signalling

Thomas H. Hancock



Abstract

It is becoming accepted that treatment with hydrogen gas (H2) has profound and often beneficial effects on cells from both animals and plants. Future uses which have been suggested include for cancer treatment, for alleviating symptoms of Parkinson’s disease and ischemia and for improving crops in agriculture. However, besides a direct interaction with hydroxyl radicals there is little resolution of how H2 is having biological effects. Dihydrogen is known to exist in two spin states, ortho and para, and to have paramagnetic properties. The interconversion of hydrogen spin states has been reported in the presence of signaling molecules such as nitric oxide, and in the vicinity of transition metals and organometallic compounds. Therefore, it is proposed here that the relationship between the effects of hydrogen gas and paramagnetism are investigated as a possible mechanism which could account for the alterations of cell function reported following H2 treatment.

Citation

Hancock, J. T., & Hancock, T. H. (2018). Hydrogen gas, ROS metabolism and cell signaling: Are hydrogen spin states important?. Reactive Oxygen Species, 6(18),

Journal Article Type Article
Acceptance Date Aug 12, 2018
Publication Date Nov 1, 2018
Deposit Date Aug 24, 2018
Publicly Available Date Mar 29, 2024
Journal Reactive Oxygen Species
Print ISSN 2380-2367
Publisher AIMSCI Cell Med Press
Peer Reviewed Peer Reviewed
Volume 6
Issue 18
Keywords hydrogen gas, cell signalling, magnetism
Public URL https://uwe-repository.worktribe.com/output/857510
Publisher URL https://www.aimsci.com/ros/index.php/ros/article/view/164

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