Outputs (36)

Does COVID-19 cause or worsen LUT dysfunction, what are the mechanisms and possible treatments? ICI-RS 2023 (2024)
Journal Article

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and produced a worldwide pandemic in 2020. There have been 770,875,433 confirmed cases and 6,959,316 attributed deaths worldwide unt... Read More about Does COVID-19 cause or worsen LUT dysfunction, what are the mechanisms and possible treatments? ICI-RS 2023.

How does the lower urinary tract contribute to bladder sensation? ICI-RS 2023 (2023)
Journal Article

Aim: Bladder sensation is critical for coordinating voluntary micturition to maintain healthy bladder function. Sensations are initiated by the activation of sensory afferents that innervate throughout the bladder wall. However, the physiological com... Read More about How does the lower urinary tract contribute to bladder sensation? ICI-RS 2023.

25 the role of the mucosa in mediating spontaneous contractions of the pig urinary bladder (2022)
Presentation / Conference Contribution

The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder (2021)
Journal Article

Purpose: The urinary bladder generates phasic contractions via action potentials generated in pre- and then postganglionic neurons. Whilst the frequency-dependence of postganglionic neurons to generate contractions has been quantified, the dynamic ra... Read More about The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder.

ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia? (2020)
Journal Article

Introduction: The following is a report on the proceedings of the 2019 International Consultation on Incontinence-Research Society nocturia think tank (NTT). Objectives: The objectives of the 2019 NTT were as follows: (a) to evaluate the role of urot... Read More about ICI-RS 2019 nocturia think tank: How can experimental science guide us in understanding the pathophysiology of nocturia?.

Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice (2019)
Journal Article

© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and purpose: PDE inhibitors such as sildenafil alleviate lower urinary tract symptoms; however, a comple... Read More about Influence of sildenafil on the purinergic components of nerve-mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice.

Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder (2019)
Journal Article

Micromotions are phasic contractions of the bladder wall. During urine storage, such phasic activity has little effect on intravesical pressure, however, changed motile activity may underlie urodynamic observations such as detrusor overactivity. The... Read More about Modulation of bladder wall micromotions alters intravesical pressure activity in the isolated bladder.

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties (2018)
Journal Article

© 2018 The oncogene ERG encodes an ETS family transcription factor and is implicated in blood, vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is alternatively spliced; of particular interest is its cassette exon... Read More about The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Mild external heating and reduction in spontaneous contractions of the bladder (2017)
Journal Article

© 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd Objectives: To measure the effect of external heating on bladder wall contractile function, histological structure and expression of proteins related t... Read More about Mild external heating and reduction in spontaneous contractions of the bladder.

Cell biology (2017)
Book Chapter

There is no abstract

Is electrolyte transfer across the urothelium important?: ICI-RS 2015 (2017)
Journal Article

Abstract AIMS: This article summarizes discussion at the International Consultation on Incontinence Research Society (ICI-RS) 2015 meeting of urine modification in the urinary tract by the urothelium. It considers the literature and proposes pertin... Read More about Is electrolyte transfer across the urothelium important?: ICI-RS 2015.

Can we define and characterize the aging lower urinary tract?-ICI-RS 2015 (2017)
Journal Article

The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is whether biological age is the v... Read More about Can we define and characterize the aging lower urinary tract?-ICI-RS 2015.

Can we define and characterize the aging lower urinary tract?—ICI-RS 2015 (2017)
Journal Article

© 2017 Wiley Periodicals, Inc. The prevalence of lower urinary tract (LUT) symptoms increases with age but the etiology is unknown. This article aims to identify research directions that clarify the basis of this association. The initial question is... Read More about Can we define and characterize the aging lower urinary tract?—ICI-RS 2015.

Estimation of bladder contractility from intravesical pressure–volume measurements (2016)
Journal Article

© 2016 Wiley Periodicals, Inc. Aims: To describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics. Methods: Subtracted detrusor pressure and voided flow were... Read More about Estimation of bladder contractility from intravesical pressure–volume measurements.

The role of the mucosa in normal and abnormal bladder function (2016)
Journal Article

© 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society) The internal face of the detrusor smooth muscle wall of the urinary bladder is covered by a mucosa, separating muscle from the hostile environment of urine.... Read More about The role of the mucosa in normal and abnormal bladder function.

796 Expression of aquaporin channels in pig urinary bladder (2015)
Journal Article

Physiological and pathophysiological implications of micromotion activity in urinary bladder function (2015)
Journal Article

© 2014 Scandinavian Physiological Society. 'Micromotions' is a term signifying the presence of localized microcontractions and microelongations, alongside non-motile areas. The motile areas tend to shift over the bladder surface with time, and the in... Read More about Physiological and pathophysiological implications of micromotion activity in urinary bladder function.

Identification of Anoctamin-1 in the interstitial cells of rat bladder and the effect of T16Ainh-A01 on the phasic activity of bladder strips (2014)
Presentation / Conference Contribution

The effects of heating from 37-50oC on bladder spontaneous contractions (2014)
Presentation / Conference Contribution

Anoctamin-1 in the juvenile rat urinary bladder (2014)
Journal Article

Purpose: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. Materials and Methods: Bladders from 3 week old Wistar rats were studied. End-point PCR on total mR... Read More about Anoctamin-1 in the juvenile rat urinary bladder.

What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013 (2014)
Journal Article

Aims A biomarker is an entity that measures a normal or pathological process, or the response to an intervention. A biomarker must measure exclusively and be sufficiently sensitive to the process of interest. Alternatively, a biomarker may give clues... Read More about What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013.

Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article

The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.

Phasic contractions in urinary bladder from juvenile versus adult pigs (2013)
Journal Article

The validation of a functional, isolated pig bladder model for physiological experimentation (2012)
Journal Article

Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and intravesical drug administration, intravesi... Read More about The validation of a functional, isolated pig bladder model for physiological experimentation.

Use of the isolated perfused whole pig bladder for investigating spontaneous contractions (2012)
Presentation / Conference Contribution

Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011 (2012)
Journal Article

Aims Due to an increase in aging population and changing eating habits diabetes mellitus (DM) type II is a rapidly increasing condition worldwide. Although not so detrimental as other co-morbidities, uropathy contributes to a significantly reduced qu... Read More about Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011.

Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators (2011)
Journal Article

Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth mus... Read More about Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators.

Detrusor underactivity: A plea for new approaches to a common bladder dysfunction (2011)
Journal Article

Aims: Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The pur... Read More about Detrusor underactivity: A plea for new approaches to a common bladder dysfunction.

Bladder outlet physiology in the context of lower urinary tract dysfunction (2011)
Journal Article

Physiological function of the bladder outlet is complex and symptomatic consequences can result from outlet dysfunction. Within the outlet, smooth, and skeletal muscles constitute the contractile apparatus, but additional cell types include interstit... Read More about Bladder outlet physiology in the context of lower urinary tract dysfunction.

The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats (2011)
Journal Article

What's known on the subject? and What does the study add? Although the functional significance of ICCs in the bladder is still not clear, they have been linked with detrusor overactivity. In this study we demonstrate the presence of c-kit positive in... Read More about The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats.

Use of the isolated perfused whole pig bladder for investigating the integrative physiology of the bladder (2011)
Presentation / Conference Contribution

227 Cholinergic modulation of spontaneous activity in bladder strips from the diabetic rat: Effect of the mucosa (2009)
Presentation / Conference Contribution

Cholinergic modulation of spontaneous activity in bladder strips from the diabetic rat: Effect of the mucosa (2009)
Journal Article

Identification of c-kit positive cells in rat urinary bladder and characterization of their functional role in spontaneous activity in control and diabetic bladders (2008)
Journal Article

997 Spontaneous activity in the diabetic rat bladder detrusor muscle (2007)
Presentation / Conference Contribution

Investigation of the role of TRPM8 channels in mediating contraction of the pig urinary bladder
Presentation / Conference Contribution