All Outputs (67)

Functionalized paramagnetic nanoparticles for waste water treatment (2010)
Journal Article
Elder, G. R., Duffield, J. R., Urban, I., Ratcliffe, N. M., & Patton, D. (2010). Functionalized paramagnetic nanoparticles for waste water treatment. Chemical Communications, 46(25), 4583-4585. https://doi.org/10.1039/b925933c

An approach to the design, development and implementation of a new separation technology for use in the decontamination of radioactive waste streams is reported here. Calixarene-crown-6 derivatives with terminal carboxyl groups were synthesised and a... Read More about Functionalized paramagnetic nanoparticles for waste water treatment.

Enhancing consultation practices on Air Quality Management in local authorities (2010)
Journal Article
Leksmono, N., Dorfman, P., Burnet, F., Gibbs, D., Longhurst, J., & Weitkamp, E. (2010). Enhancing consultation practices on Air Quality Management in local authorities. Journal of Environmental Planning and Management, 53(5), 559-571. https://doi.org/10.1080/09640561003633680

Schedule 11 of the Environment Act 1995 underpins the requirement for consultation on air quality issues. The ongoing air quality review and assessment process represents one of the largest locally based science policy and communication initiatives e... Read More about Enhancing consultation practices on Air Quality Management in local authorities.

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells (2010)
Journal Article
Patsos, H. A., Greenhough, A., Hicks, D. J., Al Kharusi, M., Collard, T. J., Lane, J. D., …Williams, A. C. (2010). The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. International Journal of Oncology, 37(1), 187-193. https://doi.org/10.3892/ijo_00000666

Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of patients presenting with advanced disease will remain resistant t... Read More about The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.

Instrumental considerations for the effective operation of short, highly efficient fused-core columns. Investigation of performance at high flow rates and elevated temperatures (2010)
Journal Article
McCalley, D. V. (2010). Instrumental considerations for the effective operation of short, highly efficient fused-core columns. Investigation of performance at high flow rates and elevated temperatures. Journal of Chromatography A, 1217(27), 4561-4567. https://doi.org/10.1016/j.chroma.2010.04.070

Fused core or superficially porous columns offer the advantages of higher efficiency compared with totally porous columns of the same particle size, but similar operating pressures. However, their performance may be adversely affected by extra-column... Read More about Instrumental considerations for the effective operation of short, highly efficient fused-core columns. Investigation of performance at high flow rates and elevated temperatures.

Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening (2010)
Journal Article
Rawson, F. J., Jackson, S. K., & Hart, J. P. (2010). Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening. Analytical Letters, 43(10-11), 1790-1800. https://doi.org/10.1080/00032711003653908

The aim of the current work was to characterize the electrochemical behavior of DNA and its derivatives using screen printed carbon electrodes (SPCEs). Differential pulse voltammetry (DPV) was carried out on guanine, adenine, 8-oxyguanine, 8-deoxygau... Read More about Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening.

Penetrative convection via internal heating in anisotropic porous media (2010)
Journal Article
Capone, F., Gentile, M., & Hill, A. A. (2010). Penetrative convection via internal heating in anisotropic porous media. Mechanics Research Communications, 37(5), 441-444. https://doi.org/10.1016/j.mechrescom.2010.06.005

Penetrative convection in an anisotropic porous medium is simulated via internal heating. We consider both internal heat sources and sinks, where the porous medium has constant anisotropic thermal diffusivity and non-homogeneous permeability. Both li... Read More about Penetrative convection via internal heating in anisotropic porous media.

Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy (2010)
Journal Article
Hows, J., Wexler, S., Kemp, K. C., Morse, R., Wexler, S. A., Cox, C., …Donaldson, C. (2010). Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy. Annals of Hematology, 89(7), 701-713. https://doi.org/10.1007/s00277-009-0896-2

Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be i... Read More about Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy.

Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+ (2010)
Journal Article
Piano, M., Serban, S., Pittson, R., Drago, G. A., & Hart, J. P. (2010). Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+. Talanta, 82(1), 34-37. https://doi.org/10.1016/j.talanta.2010.03.051

A biosensor for the measurement of lactate in serum has been developed, which is based on a screen-printed carbon electrode, modified with Meldola's Blue-Reinecke Salt (MBRS-SPCE), coated with the enzyme lactate dehydrogenase NAD+ dependent (from Por... Read More about Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+.

Magnetizable antibody-like proteins (2010)
Journal Article
Dehal, P. K., Livingston, C. F., Dunn, C. G., Buick, R., Luxton, R. W., & Pritchard, D. J. (2010). Magnetizable antibody-like proteins. Biotechnology Journal, 5(6), 596-604. https://doi.org/10.1002/biot.200900273

Use of paramagnetic particles to isolate molecules or cells from complex media is well established. Typically, particles are manufactured and coated with a biological molecule that confers specific biorecognition. Incubation of particles with sample... Read More about Magnetizable antibody-like proteins.

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (2010)
Journal Article
progesterone receptors in breast cancer. Archives of Pathology and Laboratory Medicine, 134(6), 907-922

Purpose: To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers. Methods: The American... Read More about American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease (2010)
Journal Article
Ahmed, I., Probert, C., Ratcliffe, N. M., & Greenwood, R. (2010). W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease

Introduction: Crohn's disease (CD) and ulcerative colitis (UC) are diagnosed using invasive investigations which patients find unpleasant. Non-invasive modalities to asses the clinical course of the disease are yet to be adopted. Volatile organic com... Read More about W1908 diagnostic potential of volatile organic compounds in inflammatory bowel disease.

Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells (2010)
Journal Article
Ieropoulos, I., Winfield, J., & Greenman, J. (2010). Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells. Bioresource Technology, 101(10), 3520-3525. https://doi.org/10.1016/j.biortech.2009.12.108

To process large volumes of wastewater, microbial fuel cells (MFCs) would require anodophilic bacteria preferably operating at high flow-rates. The effect of flow-rate on different microbial consortia was examined during anodic biofilm development, u... Read More about Effects of flow-rate, inoculum and time on the internal resistance of microbial fuel cells.

Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA (2010)
Journal Article
Nurmemmedov, E., Yengo, R. K., Ladomery, M., & Thunnissen, M. M. (2010). Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA. Archives of Biochemistry and Biophysics, 497(1-2), 21-27. https://doi.org/10.1016/j.abb.2010.02.013

The zinc finger transcription factor Wilms tumour protein (WT 1) is known for its essential involvement in the development of the genitourinary system as well as of other organs and tissues. WT 1 is capable of selectively binding either DNA or mRNA t... Read More about Kinetic behaviour of WT 1's zinc finger domain in binding to the alpha-actinin-1 mRNA.

Study of the selectivity, retention mechanisms and performance of alternative silica-based stationary phases for separation of ionised solutes in hydrophilic interaction chromatography (2010)
Journal Article
McCalley, D. V. (2010). Study of the selectivity, retention mechanisms and performance of alternative silica-based stationary phases for separation of ionised solutes in hydrophilic interaction chromatography. Journal of Chromatography A, 1217(20), 3408-3417. https://doi.org/10.1016/j.chroma.2010.03.011

The separation of a mixture of neutral, strongly acidic and strongly basic compounds was studied in hydrophilic interaction chromatography using a bare silica phase, and bonded silica phases with diol, zwitterionic, amide and hydrophilic/hydrophobic... Read More about Study of the selectivity, retention mechanisms and performance of alternative silica-based stationary phases for separation of ionised solutes in hydrophilic interaction chromatography.

Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system (2010)
Journal Article
Taylor, B., & Greenman, J. (2010). Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system. Journal of Breath Research, 4(1), 017107. https://doi.org/10.1088/1752-7155/4/1/017107

The pH of the tongue biofilm is likely to influence microbial composition and ecology with consequent effects on the metabolic activities and generation of volatile sulfur compounds (VSC) and other malodour gasses. The aim of this study was to identi... Read More about Modelling the effects of pH on tongue biofilm using a sorbarod biofilm perfusion system.

Short-term effect of deep shade and enhanced nitrogen supply on Sphagnum capillifolium morphophysiology (2010)
Journal Article
Bonnett, S. A., Ostle, N., & Freeman, C. (2010). Short-term effect of deep shade and enhanced nitrogen supply on Sphagnum capillifolium morphophysiology. Plant Ecology, 207(2), 347-358. https://doi.org/10.1007/s11258-009-9678-0

Sphagnum capillifolium mesocosms collected from an ombrotrophic blanket bog were subjected to controlled photon flux densities (control and shaded) and nitrogen (low and high) treatments between November 2003 and August 2004. Shading significantly re... Read More about Short-term effect of deep shade and enhanced nitrogen supply on Sphagnum capillifolium morphophysiology.

Improved energy output levels from small-scale Microbial Fuel Cells (2010)
Journal Article
Ieropoulos, I., Greenman, J., & Melhuish, C. (2010). Improved energy output levels from small-scale Microbial Fuel Cells. Bioelectrochemistry, 78(1), 44-50. https://doi.org/10.1016/j.bioelechem.2009.05.009

This study reports on the findings from the investigation into small-scale (6.25mL) MFCs, connected together as a network of multiple units. The MFCs contained unmodified (no catalyst) carbon fibre electrodes and for initial and later experiments, a... Read More about Improved energy output levels from small-scale Microbial Fuel Cells.

Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis (2010)
Journal Article
Honeychurch, K. C., Gilbert, L., & Hart, J. P. (2010). Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis. Analytical and Bioanalytical Chemistry, 396(8), 3103-3111. https://doi.org/10.1007/s00216-010-3534-x

Cobalt phthalocyanine-modified screen-printed carbon electrodes (CoPC-SPCEs) have been investigated as disposable sensors for the measurement of citric acid. The analyte was found to undergo an electrocatalytic oxidation process involving the Co2+/Co... Read More about Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine- modified screen-printed carbon electrode and its application in pharmaceutical and food analysis.

The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells (2010)
Journal Article
Greenhough, A., Wallam, C. A., Hicks, D. J., Moorghen, M., Williams, A. C., & Paraskeva, C. (2010). The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells. Oncogene, 29(23), 3398-3410. https://doi.org/10.1038/onc.2010.94

Overexpression of cyclooxygenase-2 (COX-2) and elevated levels of its enzymatic product prostaglandin E2 (PGE 2) occur in the majority of colorectal cancers and have important roles in colorectal tumorigenesis. However, despite the established prosur... Read More about The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells.

Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins (2010)
Journal Article
Pemberton, R., Rawson, F. J., Xu, J., Pittson, R., Drago, G. A., Griffiths, J., …Hart, J. P. (2010). Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins. Microchimica Acta, 170(3), 321-330. https://doi.org/10.1007/s00604-010-0326-0

Microband biosensors were fabricated from a screen-printed water-based carbon ink containing cobalt phthalocyanine redox mediator and glucose oxidase or lactate oxidase enzyme. The microbiosensors were characterised for their ability to monitor ferro... Read More about Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins.