All Outputs (304)

The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety (2012)
Journal Article

Symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by acute administration of GABAA receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose-related, by comparing a 0.5 mg dose (consid... Read More about The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO2-induced anxiety.

Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic (2012)
Journal Article

Previous studies have shown that subjective and objective symptoms of anxiety induced by 7.5% CO2 inhalation can be attenuated by anxiolytics such as lorazepam and, to a lesser extent, paroxetine. Venlafaxine and pregabalin, two other licensed treatm... Read More about Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic.

Reflections on resilience: A psychosocial exploration of the life long impact of having been in care during childhood (2012)
Journal Article

Previous studies of adults who grew up in care as children show that they are over-represented in the homeless population, the mental health system, the prison population and substance abuse. However there are other adults who grew up in care who ach... Read More about Reflections on resilience: A psychosocial exploration of the life long impact of having been in care during childhood.

The effect of patient positioning on the duration of venous reflux in Duplex ultrasound for venous insufficiency (2012)
Journal Article

Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia (2012)
Journal Article

Wernicke's aphasia is a condition which results in severely disrupted language comprehension following a lesion to the left temporo-parietal region. A phonological analysis deficit has traditionally been held to be at the root of the comprehension im... Read More about Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia.

The effects of 7.5% carbon dioxide inhalation on task performance in healthy volunteers (2011)
Journal Article

Studies have shown that anxiety can positively or negatively affect performance with respect to focusing of attention or distractibility, subjective workload and effort (Humphreys and Revelle, 1984). The inhalation of carbon dioxide (CO2) is associat... Read More about The effects of 7.5% carbon dioxide inhalation on task performance in healthy volunteers.

Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety (2011)
Journal Article

We have validated the use of prolonged inhalation of 7.5% carbon dioxide (CO2) as a human model of anxiety and have shown that drugs from two prototypical classes of anxiolytics, benzodiazepines and a serotonin reuptake inhibitor, attenuate CO2-induc... Read More about Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety.

Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression (2011)
Journal Article

Increased vigilance to threat-related stimuli is thought to be a core cognitive feature of anxiety. We sought to investigate the cognitive impact of experimentally induced anxiety, by means of a 7.5% CO2 challenge, which acts as an unconditioned anxi... Read More about Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression.

Abducting both arms improves stability during breast radiotherapy: The Bi Arm study in radiotherapy (2010)
Journal Article

Background: A randomised study to investigate whether bilateral arm abduction is superior to unilateral abduction with respect to stability using shifts on treatment as the main outcome measure. Material and Methods: 50 consecutive female patients we... Read More about Abducting both arms improves stability during breast radiotherapy: The Bi Arm study in radiotherapy.

Specific aspects of gastro-intestinal transit in children for drug delivery design (2010)
Journal Article

This mini-review discusses relevant aspects of gastro-intestinal transit in different ages of paediatric patients with an attempt to highlight factors which should be considered in oral dosage form design, in particular multi-particulate dosage forms... Read More about Specific aspects of gastro-intestinal transit in children for drug delivery design.

Abducting both arms improves stability during breast radiotherapy: The Bi Arm study in breast (2009)
Journal Article

Background: A randomised study to investigate whether bilateral arm abduction is superior to unilateral abduction with respect to stability using shifts on treatment as the main outcome measure.Material and Methods: 50 consecutive female patients wer... Read More about Abducting both arms improves stability during breast radiotherapy: The Bi Arm study in breast.

SPECT/CT and its role in imaging and oncology (2009)
Journal Article

PET/CT: Service provision and understanding patients’ needs (2009)
Journal Article

Practical PET/CT: Reflections and skill development (2009)
Journal Article

Topographic indications of emerging keratoconus in teenage New Zealanders (2007)
Journal Article

PURPOSE: To screen a population of teenagers for emerging topographic signs of keratoconus (KC), with particular reference to ethnicity. METHODS: Corneal topography, visual acuity, and an environmental risk factor analysis were included in a screenin... Read More about Topographic indications of emerging keratoconus in teenage New Zealanders.

Cerebral reserve stress testing using Tc99m HMPAO SPECT imaging: A case study (2007)
Journal Article

A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers (2007)
Journal Article

The inhalation of 7.5% carbon dioxide (CO2) in healthy subjects produces an increase in blood pressure and heart rate, and increased feelings of anxiety, fear and tension (Bailey et al. 2005). As this state is similar to that of general anxiety rathe... Read More about A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers.

The Nepal longitudinal study: Biometric characteristics of developing eyes (2006)
Journal Article

PURPOSE. To identify differences in potential biometric markers for predicting refractive error in school children. METHODS. Biometric data on 895 Tibetan children, aged 6 to 18 years, residing in Katmandu, Nepal, were collected biennially from 1992... Read More about The Nepal longitudinal study: Biometric characteristics of developing eyes.

A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults (2004)
Journal Article

One of the most popular herbal remedies for the alleviation of sleep problems is valerian. However, research into valerian is sparse, and studies differ greatly with respect to design, measures, and preparations used. This clinical study used standar... Read More about A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults.

The relationship between the sagitta of the anterior corneal surface and refractive error of the eye (2004)
Journal Article

Changes in the sagitta of the anterior corneal surface associated with a change in the corneal radius of curvature have been used to calculate the change in refractive error of the eye in two areas: the ablation depth for laser surgery, and the chang... Read More about The relationship between the sagitta of the anterior corneal surface and refractive error of the eye.