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All Outputs (135)

α- and β-secretase: Profound changes in Alzheimer's disease (2002)
Journal Article
Allen, S. J., Dawbarn, D., Tyler, S. J., & Wilcock, G. (2002). α- and β-secretase: Profound changes in Alzheimer's disease. Biochemical and Biophysical Research Communications, 299(3), 373-376. https://doi.org/10.1016/S0006-291X%2802%2902635-9

The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of β-amyloid (Aβ) peptide, which is cleaved from Amyloid Precursor Protein (APP) by the enzyme β-secretase. Only small amounts of Aβ form in normal... Read More about α- and β-secretase: Profound changes in Alzheimer's disease.

No seasonality in month of birth of inflammatory bowel disease cases: A prospective population based study of British under 20 year olds (2002)
Journal Article
Card, T. R., Sawczenko, A., Sandhu, B., & Logan, R. F. A. (2002). No seasonality in month of birth of inflammatory bowel disease cases: A prospective population based study of British under 20 year olds. Gut, 51(6), 814-815. https://doi.org/10.1136/gut.51.6.814

Prenatal or perinatal environmental exposures have been postulated to change the risk of inflammatory bowel disease (IBD) later in life.1 One manifestation of this, perhaps because of early and seasonal infectious exposure, might be an association be... Read More about No seasonality in month of birth of inflammatory bowel disease cases: A prospective population based study of British under 20 year olds.

The speech and language of children aged 25 months: Descriptive data from the Avon longitudinal study of parents and children (2002)
Journal Article
Northstone, K., Beveridge, M., Loader, S., ALSPAC team, T., & Roulstone, S. (2002). The speech and language of children aged 25 months: Descriptive data from the Avon longitudinal study of parents and children. Early Child Development and Care, 172(3), 259-268. https://doi.org/10.1080/03004430212126

A major epidemiological study, the Avon Longitudinal Study of Parents and Children, has provided the opportunity for a population study of children's speech and language. Data collected via direct assessments and maternal self-completion questionnair... Read More about The speech and language of children aged 25 months: Descriptive data from the Avon longitudinal study of parents and children.

Breathing control techniques in the management of asthma (2002)
Journal Article
Kellett, C., & Mullan, J. (2002). Breathing control techniques in the management of asthma. Physiotherapy, 88(12), 751-758. https://doi.org/10.1016/S0031-9406%2805%2960719-5

Asthma is a growing problem, both in the United Kingdom and throughout the world. It is estimated that in the UK over 3.4 million people have asthma (NAC, 1999). Consequently the economic burden is huge. The annual cost of asthma to the National Heal... Read More about Breathing control techniques in the management of asthma.

Evaluating a new course in postnatal care (2002)
Journal Article
Mitchell, M., & Doyle, M. (2002). Evaluating a new course in postnatal care. British Journal of Midwifery, 10(12), 746-750. https://doi.org/10.12968/bjom.2002.10.12.746

An innovative course has been developed and implemented to enable midwives to extend their role in the postnatal period. This is in response to the challenge for midwives to enhance their public health role. On completion of the course participants f... Read More about Evaluating a new course in postnatal care.

Blood and straw (2002)
Journal Article
Hall, J. (2002). Blood and straw. Third Way -London- Third Way Trust Limited-, 25(10), 11-13

Application of Markov chain Monte Carlo methods to projecting cancer incidence and mortality (2002)
Journal Article
Bray, I. (2002). Application of Markov chain Monte Carlo methods to projecting cancer incidence and mortality. Journal of the Royal Statistical Society: Series C, 51(2), 151-164. https://doi.org/10.1111/1467-9876.00260

Projections based on incidence and mortality data collected by cancer registries are important for estimating current rates in the short term, and public health planning in the longer term. Classical approaches are dependent on questionable parametri... Read More about Application of Markov chain Monte Carlo methods to projecting cancer incidence and mortality.

A structural and mechanistic investigation of the mono-O-phenylation of diols with BiPh3(OAc)2 (2002)
Journal Article
Coles, S. J., Costello, J. F., Hursthouse, M. B., & Smith, S. (2002). A structural and mechanistic investigation of the mono-O-phenylation of diols with BiPh3(OAc)2. Journal of Organometallic Chemistry, 662(1-2), 98-104. https://doi.org/10.1016/S0022-328X%2802%2901895-8

The mono-O-phenylation of enantiomerically pure pinanediol 2 using BiPh3(OAc)2 1 and the biphenyl-2,2′-ylenephenylbismuth analogue 9 has been investigated. It is postulated that reductive elimination at the trigonal bipyramidal bismuth (V) centre of... Read More about A structural and mechanistic investigation of the mono-O-phenylation of diols with BiPh3(OAc)2.

Evidence-based practice in health and social care: Where are we now? (2002)
Journal Article
Swinkels, A., Albarran, J., Means, R., Mitchell, T., & Stewart, M. (2002). Evidence-based practice in health and social care: Where are we now?. Journal of Interprofessional Care, 16(4), 335-347. https://doi.org/10.1080/1356182021000008265

This paper explores evidence-based practice (EBP) in health and social care in the UK from the individual perspectives of professionals in physiotherapy, midwifery, nursing and social care. The present interest in EBP emerges as a natural derivative... Read More about Evidence-based practice in health and social care: Where are we now?.

The case for urban prehospital thrombolysis (2002)
Journal Article
Benger, J. (2002). The case for urban prehospital thrombolysis. Emergency Medicine Journal, 19(5), 441-443. https://doi.org/10.1136/emj.19.5.441

This is the first part in a debate on the benefits and disadvantages of urban prehospital thrombolysis. I put the case for prehospital thrombolysis in the urban environment and argue that it is a rational development that will save lives and reduce l... Read More about The case for urban prehospital thrombolysis.

A multimethod approach to the evaluation of community preschool speech and language therapy provision (2002)
Journal Article
Glogowska, M., Campbell, R., Peters, T. J., Roulstone, S., & Enderby, P. (2002). A multimethod approach to the evaluation of community preschool speech and language therapy provision. Child: Care, Health and Development, 28(6), 513-521. https://doi.org/10.1046/j.1365-2214.2002.00297.x

Objectives. The paper presents a research study investigating the effectiveness and acceptability of community speech and language therapy provision for preschool children with early speech/language delays. As a 'worked example', it demonstrates the... Read More about A multimethod approach to the evaluation of community preschool speech and language therapy provision.

Prehospital thrombolysis: Lessons from Sweden and their application to the United Kingdom (2002)
Journal Article
Benger, J., Karlsten, R., & Eriksson, B. (2002). Prehospital thrombolysis: Lessons from Sweden and their application to the United Kingdom. Emergency Medicine Journal, 19, 578-583. https://doi.org/10.1136/emj.19.6.578

Objective: To study the successful implementation of paramedic administered prehospital thrombolysis in Sweden, and to consider the implications of this for the UK. Methods: A series of research visits were undertaken, including visits to Uppsala Hos... Read More about Prehospital thrombolysis: Lessons from Sweden and their application to the United Kingdom.