α- and β-secretase: Profound changes in Alzheimer's disease
(2002)
Journal Article
Allen, S. J., Dawbarn, D., Tyler, S. J., & Wilcock, G. (2002). α- and β-secretase: Profound changes in Alzheimer's disease. Biochemical and Biophysical Research Communications, 299(3), 373-376. https://doi.org/10.1016/S0006-291X%2802%2902635-9
The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of β-amyloid (Aβ) peptide, which is cleaved from Amyloid Precursor Protein (APP) by the enzyme β-secretase. Only small amounts of Aβ form in normal... Read More about α- and β-secretase: Profound changes in Alzheimer's disease.