Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites

Dao, Trong Tuan; De Mattos-Shipley, Kate M; Prosser, Ian M; Williams, Katherine; Zacharova, Marija K; Lazarus, Colin M; Willis, Christine L; Bailey, Andrew M

doi:10.3389/ffunb.2021.632542

All Outputs (3)

The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder (2021)
Journal Article

Purpose: The urinary bladder generates phasic contractions via action potentials generated in pre- and then postganglionic neurons. Whilst the frequency-dependence of postganglionic neurons to generate contractions has been quantified, the dynamic ra... Read More about The frequency-dependence of pre- and postganglionic nerve stimulation of pig and rat bladder.

Reproductive history determines ERBB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model (2021)
Journal Article

Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes B... Read More about Reproductive history determines ERBB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model.

Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites (2021)
Journal Article

The use of filamentous fungi as cellular factories, where natural product pathways can be refactored and expressed in a host strain, continues to aid the field of natural product discovery. Much work has been done to develop host strains which are ge... Read More about Cleaning the cellular factory: Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites.