Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing

Hawksworth, Joseph; Satchwell, Timothy J.; Meinders, Marjolein; Daniels, Deborah E.; Regan, Fiona; Thornton, Nicole M.; Wilson, Marieangela C.; Dobbe, Johannes G.G.; Streekstra, Geert J.; Trakarnsanga, Kongtana; Heesom, Kate J.; Anstee, David J.; Frayne, Jan; Toye, Ashley M.

doi:10.15252/emmm.201708454

All Outputs (3)

Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi (2018)
Journal Article

Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crysta... Read More about Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi.

Non-muscle myosin ii drives vesicle loss during human reticulocyte maturation (2018)
Journal Article

The process of maturation of reticulocytes into fully mature erythrocytes that occurs in the circulation is known to be characterized by a complex interplay between loss of cell surface area and volume, removal of remnant cell organelles and redundan... Read More about Non-muscle myosin ii drives vesicle loss during human reticulocyte maturation.

Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing (2018)
Journal Article

Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor b... Read More about Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.