BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer

Shafei, Mai Ahmed; Forshaw, Thomas; Davis, Jasmine; Flemban, Arwa; Qualtrough, David; Dean, Sarah; Perks, Claire; Dong, Ming; Newman, Robert; Conway, Myra Elizabeth

doi:10.18632/oncotarget.27607

All Outputs (3)

Differential expression of the BCAT isoforms between breast cancer subtypes (2020)
Journal Article

© 2020, The Author(s). Background: Biological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have distinct locoregional patterns. This is related to metabolic phenotype, where... Read More about Differential expression of the BCAT isoforms between breast cancer subtypes.

Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients (2020)
Journal Article

Insulin-like growth factor binding protein 3 (IGFBP-3) plays a key role in breast cancer progression and was recently shown to bind to the chaperone protein glucose-regulated protein 78 (GRP78); however, the clinical significance of this association... Read More about Interaction between GRP78 and IGFBP-3 affects tumourigenesis and prognosis in breast cancer patients.

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer (2020)
Journal Article

The cytosolic branched chain aminotransferase (BCATc) protein has been found to be highly expressed in breast cancer subtypes, including triple negative breast cancer (TNBC), compared with normal breast tissue. The catabolism of branched-chain amino... Read More about BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer.