Some factors that can lead to poor peak shape in hydrophilic interaction chromatography, and possibilities for their remediation

Heaton, James C.; Heaton, James; McCalley, David V.

doi:10.1016/j.chroma.2015.10.056

All Outputs (5)

Effect of mobile phase additives on solute retention at low aqueous pH in hydrophilic interaction liquid chromatography (2016)
Journal Article

© 2016 Elsevier B.V. Trifluoracetic acid (TFA) added to the aqueous acetonitrile mobile phase induces some unexpected changes in the ionic component of retention in hydrophilic interaction separations when using Type B silica and amide-bonded silica... Read More about Effect of mobile phase additives on solute retention at low aqueous pH in hydrophilic interaction liquid chromatography.

Recent developments in support materials for use in high performance liquid chromatography (2016)
Journal Article

A number of advances have taken place in the last decade in the area of support materials for high performance liquid chromatography (HPLC). These developments have included the use of very small porous particles (< 2.0 micron diameter), new types of... Read More about Recent developments in support materials for use in high performance liquid chromatography.

Distinction of synthetic dl-α-tocopherol from natural vitamin E (d-α-tocopherol) by reversed-phase liquid chromatography. Enhanced selectivity of a polymeric C18 stationary phase at low temperature and/or at high pressure (2016)
Journal Article

© 2016 Elsevier B.V. Separation of diastereomers of DL-α-tocopherol was studied by reversed-phase liquid chromatography using three types of stationary phases, polymeric ODS, polymeric C30, and monomeric ODS. Polymeric ODS stationary phase (Inertsil... Read More about Distinction of synthetic dl-α-tocopherol from natural vitamin E (d-α-tocopherol) by reversed-phase liquid chromatography. Enhanced selectivity of a polymeric C18 stationary phase at low temperature and/or at high pressure.

Core-Shell, Ultrasmall Particles, Monoliths, and Other Support Materials in High-Performance Liquid Chromatography (2016)
Journal Article

A review of the developments that have taken place in the area of supports for high performance liquid chromatography in recent years.

Some factors that can lead to poor peak shape in hydrophilic interaction chromatography, and possibilities for their remediation (2016)
Journal Article

© 2015 Elsevier B.V. Some factors which present difficulties for obtaining good peak shape in hydrophilic interaction chromatography (HILIC) were studied. The effect of injection solvent composition and volume was systematically investigated using a... Read More about Some factors that can lead to poor peak shape in hydrophilic interaction chromatography, and possibilities for their remediation.