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Anoctamin-1 in the juvenile rat urinary bladder (2014)
Journal Article
Bijos, D. A., Drake, M. J., & Vahabi, B. (2014). Anoctamin-1 in the juvenile rat urinary bladder. PLoS ONE, 9(9), https://doi.org/10.1371/journal.pone.0106190

Purpose: To investigate presence, location and functional role of calcium-activated chloride channel (CaCC) Anoctamin-1 (Ano1) in rat urinary bladder. Materials and Methods: Bladders from 3 week old Wistar rats were studied. End-point PCR on total mR... Read More about Anoctamin-1 in the juvenile rat urinary bladder.

What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013 (2014)
Journal Article
Birder, L. A., Fry, C. H., Sahai, A., Vahabi, B., Kanai, A. J., & Birder, L. A. (2014). What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013. Neurourology and Urodynamics, 33(5), 602-605. https://doi.org/10.1002/nau.22558

Aims A biomarker is an entity that measures a normal or pathological process, or the response to an intervention. A biomarker must measure exclusively and be sufficiently sensitive to the process of interest. Alternatively, a biomarker may give clues... Read More about What is the role for biomarkers for lower urinary tract disorders? ICI-RS 2013.

Trpm8 agonists modulate contraction of the pig urinary bladder (2013)
Journal Article
Parsons, B. A., Drake, M. J., Vahabi, B., Parsons, B. A., Doran, O., Rhodes, A., …Drake, M. (2013). Trpm8 agonists modulate contraction of the pig urinary bladder. Canadian Journal of Physiology and Pharmacology, 91(7), 503-509. https://doi.org/10.1139/cjpp-2012-0406

The transient receptor potential melastin-8 (TRPM8) channel is activated by the "cooling" compounds menthol and icilin. Pathophysiologically, it is implicated in the overactive bladder and bladder cooling reflex, but the activity of TRPM8 in normal b... Read More about Trpm8 agonists modulate contraction of the pig urinary bladder.

The validation of a functional, isolated pig bladder model for physiological experimentation (2012)
Journal Article
Fry, C. H., Drake, M. J., Parsons, B. A., Gammie, A., & Vahabi, B. (2012). The validation of a functional, isolated pig bladder model for physiological experimentation. Frontiers in Pharmacology, 3 APR(52), 1-8. https://doi.org/10.3389/fphar.2012.00052

Characterizing the integrative physiology of the bladder requires whole organ preparations. The purpose of this study was to validate an isolated large animal (pig) bladder preparation, through arterial and intravesical drug administration, intravesi... Read More about The validation of a functional, isolated pig bladder model for physiological experimentation.

Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011 (2012)
Journal Article
Chacko, S., Birder, L., Kirschner-Hermanns, R., Daneshgari, F., Vahabi, B., & Oelke, M. (2012). Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011. Neurourology and Urodynamics, 31(3), 359-364. https://doi.org/10.1002/nau.22228

Aims Due to an increase in aging population and changing eating habits diabetes mellitus (DM) type II is a rapidly increasing condition worldwide. Although not so detrimental as other co-morbidities, uropathy contributes to a significantly reduced qu... Read More about Does diabetes mellitus-induced bladder remodeling affect lower urinary tract function?: ICI-RS 2011.

Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators (2011)
Journal Article
Sellers, D. J., McKay, N. G., Vahabi, B., & Lawson, K. (2011). Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators. European Journal of Pharmacology, 660(2-3), 431-437. https://doi.org/10.1016/j.ejphar.2011.03.053

Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth mus... Read More about Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: Effect of potassium channel modulators.

Bladder outlet physiology in the context of lower urinary tract dysfunction (2011)
Journal Article
Sadananda, P., Vahabi, B., & Drake, M. J. (2011). Bladder outlet physiology in the context of lower urinary tract dysfunction. Neurourology and Urodynamics, 30(5), 708-713. https://doi.org/10.1002/nau.21137

Physiological function of the bladder outlet is complex and symptomatic consequences can result from outlet dysfunction. Within the outlet, smooth, and skeletal muscles constitute the contractile apparatus, but additional cell types include interstit... Read More about Bladder outlet physiology in the context of lower urinary tract dysfunction.

Detrusor underactivity: A plea for new approaches to a common bladder dysfunction (2011)
Journal Article
Van Koeveringe, G. A., Vahabi, B., Andersson, K. E., Kirschner-Herrmans, R., & Oelke, M. (2011). Detrusor underactivity: A plea for new approaches to a common bladder dysfunction. Neurourology and Urodynamics, 30(5), 723-728. https://doi.org/10.1002/nau.21097

Aims: Detrusor underactivity (DU) is defined by the International Continence Society as a contraction of reduced strength and/or duration resulting in prolonged or incomplete emptying of the bladder but has yet received only little attention. The pur... Read More about Detrusor underactivity: A plea for new approaches to a common bladder dysfunction.

The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats (2011)
Journal Article
Sellers, D. J., McKay, N. G., Vahabi, B., & Lawson, K. (2011). The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats. BJU International, 107(9), 1480-1487. https://doi.org/10.1111/j.1464-410X.2010.09507.x

What's known on the subject? and What does the study add? Although the functional significance of ICCs in the bladder is still not clear, they have been linked with detrusor overactivity. In this study we demonstrate the presence of c-kit positive in... Read More about The role of c-kit-positive interstitial cells in mediating phasic contractions of bladder strips from streptozotocin-induced diabetic rats.

Identification of c-kit positive cells in rat urinary bladder and characterization of their functional role in spontaneous activity in control and diabetic bladders (2008)
Journal Article
Vahabi, B., Mckay, N. G., Lawson, K., & Sellers, D. J. (2008). Identification of c-kit positive cells in rat urinary bladder and characterization of their functional role in spontaneous activity in control and diabetic bladders. European Urology Supplements, 7(3), 181 - 181. https://doi.org/10.1016/S1569-9056%2807%2960992-0