Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies

Lussier, Alexandre A.; Zhu, Yiwen; Smith, Brooke J.; Simpkin, Andrew J.; Smith, Andrew D.A.C.; Suderman, Matthew J.; Walton, Esther; Ressler, Kerry J.; Dunn, Erin C.

doi:10.1080/15592294.2022.2028072

All Outputs (7)

Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children (2022)
Journal Article

Background: Maternal depression is a major determinant of offspring mental health. Yet, little is understood about how the duration and timing of maternal depression shapes youth risk for depressive symptoms, which if understood could inform when bes... Read More about Testing lifecourse theories characterising associations between maternal depression and offspring depression in emerging adulthood: The Avon Longitudinal Study of Parents and Children.

Socioeconomic changes predict genome-wide DNA methylation in childhood (2022)
Journal Article

Childhood socioeconomic position (SEP) is a major determinant of health and well-being across the entire life course. To effectively prevent and reduce health risks related to SEP, it is critical to better understand when and under what circumstances... Read More about Socioeconomic changes predict genome-wide DNA methylation in childhood.

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach (2022)
Journal Article

Background: Sensitive periods are developmental stages of heightened plasticity when life experiences, including exposure to childhood adversity, have the potential to exert more lasting impacts. Epigenetic mechanisms, including DNA methylation (DNAm... Read More about Examining the epigenetic mechanisms of childhood adversity and sensitive periods: A gene set-based approach.

Sensitive periods for the effect of childhood adversity on DNA methylation: Updated results from a prospective, longitudinal study (2022)
Journal Article

Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA) (2022)
Book Chapter

Sensitive periods are times during development when life experiences can have a greater impact on outcomes than at other periods during the life course. However, a dearth of sophisticated methods for studying time-dependent exposure-outcome relations... Read More about Statistical modeling of sensitive period effects using the structured life course modelling approach (SLCMA).

Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study (2022)
Journal Article

Mental disorders are among the most disabling health conditions globally. However, there remains a lack of valid, reliable, noninvasive, and inexpensive biomarkers to identify (at an early age) people who are at the greatest risk of experiencing a fu... Read More about Association between measures derived from children's primary exfoliated teeth and psychopathology symptoms: Results from a community-based study.

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies (2022)
Journal Article

Introduction: Biomedical research has grown increasingly cooperative through the sharing of consortia-level epigenetic data. Since consortia preprocess data prior to distribution, new processing pipelines can lead to different versions of the same d... Read More about Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies.