Colon tumour cells increase PGE 2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation

Roberts, Heather R.; Smartt, Helena J.M.; Moore, Amy E.; Williams, Ann C.; Greenhough, Alexander; Paraskeva, Christos

doi:10.1093/carcin/bgr210

All Outputs (2)

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells (2011)
Journal Article

Background: Cyclooxygenase-2 (COX-2) overexpression in colorectal cancer increases levels of its protumorigenic product prostaglandin E2 (PGE2). The recently identified colorectal tumour suppressor 15-prostaglandin dehydrogenase (15-PGDH) catalyses p... Read More about β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.

Colon tumour cells increase PGE 2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation (2011)
Journal Article

Due to poor tumour-associated vasculature, tumour cells are subjected to a fluctuating microenvironment with periods of limited oxygen and glucose availability. Adaptive mechanisms to adverse microenvironments are important for tumour cell survival.... Read More about Colon tumour cells increase PGE 2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.