LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids

Al-Kharusi, Manal R.A.; Smartt, Helena J.M.; Collard, Tracey J.; Emery, Elizabeth D.; Williams, Ann C.; Al-Kharusi, Manal H; Smartt, Helena J; Collard, Tracey J; Emery, Elizabeth D; Williams, Ann C; Greenhough, Alexander; Paraskeva, Chris

doi:10.1093/carcin/bgt020

All Outputs (2)

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk (2013)
Journal Article

The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-induc... Read More about Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids (2013)
Journal Article

Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E2 (PGE2), promoting many hallmarks of cancer. Importantly, PGE2 is reported to enhance Wnt/β-catenin signalling in colorectal carcino... Read More about LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with nsaids.