Influence of dna repair on nonlinear dose-responses for mutation

Jenkins, Gareth J.S.; Thomas, Adam D.; Bodger, Owen G.; Lewis, Paul D.; Doak, Shareen H.; Johnson, George E.; Thomas, Adam D; Jenkins, Gareth JS; Bodger, Owen; Lewis, Paul; Doak, Shareen; Johnson, George; Kaina, Bernd; Tomaszowski, Karl Heinz

doi:10.1093/toxsci/kfs341

All Outputs (2)

Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice (2013)
Journal Article

Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for S N 1 and S N 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining no... Read More about Does increase in DNA repair allow "Tolerance-to-Insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

Influence of dna repair on nonlinear dose-responses for mutation (2013)
Journal Article

Recent evidence has challenged the default assumption that all DNA-reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents methyl- and ethylmethanesulfonate and methylnitrosourea (MNU) an... Read More about Influence of dna repair on nonlinear dose-responses for mutation.