Serial high-sensitivity troponin measurements for the rapid exclusion of acute myocardial infarction in low-risk patients

Benger, Jonathan R.; Dawson, Charlotte; Bayly, Graham

Abstract

High-sensitivity troponin assays facilitate the rapid exclusion of acute myocardial infarction (AMI). However, elevated results are also seen in other conditions causing myocardial injury. Serial measurements increase the specificity for AMI, helping to rapidly identify patients for whom revascularisation may be appropriate. In this study, we explore a strategy for rapidly excluding AMI in symptomatic patients using serial high-sensitivity troponin measurements. Main findings: (1) all patients presenting more than 3 h after symptom onset with a negative result had a second negative result; (2) AMI was excluded in all patients with two results falling below the lower limit of detection of a standard troponin assay by 8 h post-symptom onset.

• Journal Article Type: Article
• Publication Date: Jul 1, 2013
• Journal: Emergency Medicine Journal
• Print ISSN: 1472-0205
• Electronic ISSN: 1472-0213
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 7
• Pages: 593-594
• DOI: https://doi.org/10.1136/emermed-2012-201574
• Keywords: acute myocardial infarction, serial high-sensitivity troponin measurements
• Public URL: https://uwe-repository.worktribe.com/output/952521