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Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease

Lawlor, Debbie A.; Smith, Andrew D.; Lindsay, Robert S.; Nelson, Scott M.; Smith, Andrew D. A. C.; Simpson, Joy; Lindsay, Robert S; Fraser, Abigail; Lawlor, Debbie A; Sattar, Naveed; Nelson, Scott M; Callaway, Mark

Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease Thumbnail


Authors

Debbie A. Lawlor

Andrew D. Smith

Robert S. Lindsay

Scott M. Nelson

Joy Simpson

Robert S Lindsay

Abigail Fraser

Debbie A Lawlor

Naveed Sattar

Scott M Nelson

Mark Callaway



Abstract

© 2016 by the Endocrine Society. Context: Maternal adiposity in pregnancy is associated with offspring adiposity and metabolic dysfunction postnatally, including greater risk of nonalcoholic fatty liver disease (NAFLD). Recent genetic analyses suggest a causal effect of greater maternal body mass index on offspring birth weightandponderal index, but the relative roles of the environment in utero or later in life remains unclear. Objective: We sought to determine whether markers of infant adiposity (birth weight, umbilical cord blood leptin, adiponectin, and lipids) were associated with markers of NAFLD in adolescence. Design, Setting, and Participants: This was aUK prospective birth cohort with 17 years of follow-up with liver function tests (aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase) (n = 1037 participants), and ultrasound scan assessed liver fat, volume, and sheer velocity at age 17 (n = 541 participants). Missing covariate data were imputed. Main Outcomes: Ultrasound and biochemical measures of NAFLD were measured. Results: Birth weight, cord blood leptin, and adiponectin were not associated with a diagnosis of NAFLD. In adjusted analyses, 2 of 42 associations attained conventional 5% levels of significance. Birth weight was positively associated with liver volume (1.0% greater per 100 g [95% confidence interval 0.5%-2.0%]). Cord high-density lipoprotein-cholesterol was positively associated with alanine aminotransferase (11.6% higher per 1 mmol/L [95% confidence interval 0.3, 23.4]); however, this association was primarily mediated via offspring adiposity. Conclusions: In this extensive analysis, we found little evidence measurements of infant fat mass and birth size were related to adolescent markers of NAFLD. The association between birth weight and adolescent liver volume may indicate the contribution of greater organ size to birth weight and tracking of organ size.

Citation

Nelson, S. M., Lindsay, R. S., Smith, A. D., Lawlor, D. A., Simpson, J., Smith, A. D. A. C., …Nelson, S. M. (2016). Cord blood adipokines and lipids and adolescent nonalcoholic fatty liver disease. Journal of Clinical Endocrinology and Metabolism, 101(12), 4661-4668. https://doi.org/10.1210/jc.2016-2604

Journal Article Type Article
Acceptance Date Sep 15, 2016
Online Publication Date Sep 20, 2016
Publication Date Dec 1, 2016
Deposit Date Nov 22, 2016
Publicly Available Date Mar 29, 2024
Journal Journal of Clinical Endocrinology and Metabolism
Print ISSN 0021-972X
Electronic ISSN 1945-7197
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 101
Issue 12
Pages 4661-4668
DOI https://doi.org/10.1210/jc.2016-2604
Keywords cord blood, liver disease
Public URL https://uwe-repository.worktribe.com/output/905595
Publisher URL http://dx.doi.org/10.1210/jc.2016-2604