Ewout W. Steyerberg
Collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER-TBI): A prospective longitudinal observational study
Steyerberg, Ewout W.; Citerio, Giuseppe; Lecky, Fiona; Manley, Geoffrey T.; Hill, Sean; Legrand, Valerie; Sorgner, Annina; Koskinen, Lars Owe; Kondziella, Daniel; Kolibay, Felix; Kolias, Angelos G.; Ketharanathan, Naomi; Katila, Ari; Kasprian, Gregor; Kalovits, Ferenc; Kalala, Jean Pierre; Jones, Kelly M.; Jiang, Ji Yao; Bovend'Eerdt, Thamar J.H.; Janssens, Koen; Ill?, Robert; Hutchinson, Peter J.; Hunfeld, Maaike; Holling, Markus; Hoefer, Stefan; Helseth, Eirik; Helbok, Raimund; Hartings, Jed A.; Haitsma, Ian; Hadzic, Ermin; Hallaert, Giorgio; Haagsma, Juanita A.; Gruen, Russel; Grigore, Zapulih; Gon?orov?, Veronika; Godbolt, Alison; Ghuysen, Alexandre; Gao, Guoyi; Galanaud, Damien; Gagliardo, Pablo; Gadda, Davide; Frantz?n, Janek; Furmanov, Alex; Frisvold, Shirin Kordasti; Florian, Stefan; Forsyth, Faye; Fossi, Francesca; Feigin, Valery L.; Feremans, Len; Fabricius, Martin; Esser, Patrick; Ercole, Ari; Eapen, George; Dreier, Jens P.; Dizdarevic, Kemal; Dippel, Diederik W.J.; Depreite...
Authors
Giuseppe Citerio
Fiona Lecky
Geoffrey T. Manley
Sean Hill
Valerie Legrand
Annina Sorgner
Lars Owe Koskinen
Daniel Kondziella
Felix Kolibay
Angelos G. Kolias
Naomi Ketharanathan
Ari Katila
Gregor Kasprian
Ferenc Kalovits
Jean Pierre Kalala
Kelly M. Jones
Ji Yao Jiang
Thamar J.H. Bovend'Eerdt
Koen Janssens
Robert
Peter J. Hutchinson
Maaike Hunfeld
Markus Holling
Stefan Hoefer
Eirik Helseth
Raimund Helbok
Jed A. Hartings
Ian Haitsma
Ermin Hadzic
Giorgio Hallaert
Juanita A. Haagsma
Russel Gruen
Zapulih Grigore
Veronika
Alison Godbolt
Alexandre Ghuysen
Guoyi Gao
Damien Galanaud
Pablo Gagliardo
Davide Gadda
Janek
Alex Furmanov
Shirin Kordasti Frisvold
Stefan Florian
Faye Forsyth
Francesca Fossi
Valery L. Feigin
Len Feremans
Martin Fabricius
Patrick Esser
Ari Ercole
George Eapen
Jens P. Dreier
Kemal Dizdarevic
Diederik W.J. Dippel
Bart Depreitere
Demeter
Francesco Della Corte
Olivier De Witte
Godard C.W. De Ruiter
Alessandra De Luca
De Keyser
Helen Dawes
Damas
Claire Dahyot-Fitzelier
Marek Czosnyka
Endre Czeiter
Nicola Curry
Maryse Cnossen
Jamie Cooper
Jonathan P. Coles
Mark Coburn
Arturo Chieregato
Keri L.H. Carpenter
Guillermo Carbayo Lozano
Peter Cameron
Ina Callebaut
Ela Cakmak
Monika Bullinger
Andras Buki
Felix Brehar
Harald Binder
Alexandra
Luigi Beretta
Maurizio Berardino
Habib Benali
Antonio Belli
Bo Michael Bellander
Caterina Frosini
Ronny Beer
Philippe Azouv
Anke Audny
Audibert
Peter Andrews
Lasse Andreassen
Nada Andelic
Andrew I.R. Maas
Andrew I. R. Maas
David K. Menon
Ewout W. Steyerberg
Giuseppe Citerio
Fiona Lecky
Geoffrey T. Manley
Sean Hill
Valerie Legrand
Annina Sorgner
Abstract
Copyright © 2014 by the Congress of Neurological Surgeons. BACKGROUND: Current classification of traumatic brain injury (TBI) is suboptimal, and management is based on weak evidence, with little attempt to personalize treatment. A need exists for new precision medicine and stratified management approaches that incorporate emerging technologies. OBJECTIVE: To improve characterization and classification of TBI and to identify best clinical care, using comparative effectiveness research approaches. METHODS: This multicenter, longitudinal, prospective, observational study in 22 countries across Europe and Israel will collect detailed data from 5400 consenting patients, presenting within 24 hours of injury, with a clinical diagnosis of TBI and an indication for computed tomography. Broader registry-level data collection in approximately 20 000 patients will assess generalizability. Cross sectional comprehensive outcome assessments, including quality of life and neuropsychological testing, will be performed at 6 months. Longitudinal assessments will continue up to 24 months post TBI in patient subsets. Advanced neuroimaging and genomic and biomarker data will be used to improve characterization, and analyses will include neuroinformatics approaches to address variations in process and clinical care. Results will be integrated with living systematic reviews in a process of knowledge transfer. The study initiation was from October to December 2014, and the recruitment period was for 18 to 24 months. EXPECTED OUTCOMES: Collaborative European NeuroTrauma Effectiveness Research in TBI should provide novel multidimensional approaches to TBI characterization and classification, evidence to support treatment recommendations, and benchmarks for quality of care. Data and sample repositories will ensure opportunities for legacy research. DISCUSSION: Comparative effectiveness research provides an alternative to reductionistic clinical trials in restricted patient populations by exploiting differences in biology, care, and outcome to support optimal personalized patient management.
Citation
Steyerberg, E. W., Citerio, G., Lecky, F., Manley, G. T., Hill, S., Legrand, V., …Sorgner, A. (2015). Collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER-TBI): A prospective longitudinal observational study. Neurosurgery, 76(1), 67-80. https://doi.org/10.1227/NEU.0000000000000575
Journal Article Type | Article |
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Publication Date | Jan 1, 2015 |
Journal | Neurosurgery |
Print ISSN | 0148-396X |
Electronic ISSN | 1524-4040 |
Publisher | Oxford University Press (OUP) |
Peer Reviewed | Not Peer Reviewed |
Volume | 76 |
Issue | 1 |
Pages | 67-80 |
DOI | https://doi.org/10.1227/NEU.0000000000000575 |
Keywords | clinical study, comparative effectiveness research, protocol, traumatic brain injury |
Public URL | https://uwe-repository.worktribe.com/output/840187 |
Publisher URL | http://doi.org/10.1227/NEU.0000000000000575 |
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