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The biology of cancer-related fatigue: a review of the literature

Cramp, Fiona; Saligan, Leorey N.; Olson, Karin; Filler, Kristin; Larkin, David; Cramp, Fiona (Alice); Sriram, Yennu; Escalante, Carmen P.; del Giglio, Auro; Kober, Kord M.; Kamath, Jayesh; Palesh, Oxana; Mustian, Karen


Fiona Cramp

Leorey N. Saligan

Karin Olson

Kristin Filler

David Larkin

Fiona Cramp
Professor in Long Term Conditions

Yennu Sriram

Carmen P. Escalante

Auro del Giglio

Kord M. Kober

Jayesh Kamath

Oxana Palesh

Karen Mustian


© 2015, Springer-Verlag Berlin Heidelberg (Outside the USA). Purpose: Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on pathways to explore or therapeutic targets to investigate. Methods: This review was completed by the Multinational Association of Supportive Care in Cancer Fatigue Study Group–Biomarker Working Group. The initial search used three terms (biomarkers, fatigue, cancer), which yielded 11,129 articles. After removing duplicates, 9145 articles remained. Titles were assessed for the keywords “cancer” and “fatigue” resulting in 3811 articles. Articles published before 2010 and those with samples


Cramp, F., Saligan, L. N., Olson, K., Filler, K., Larkin, D., Cramp, F. (., …Mustian, K. (2015). The biology of cancer-related fatigue: a review of the literature. Supportive Care in Cancer, 23(8), 2461-2478.

Journal Article Type Review
Publication Date Aug 29, 2015
Deposit Date Jun 5, 2015
Journal Supportive Care in Cancer
Print ISSN 0941-4355
Electronic ISSN 1433-7339
Publisher Springer (part of Springer Nature)
Peer Reviewed Peer Reviewed
Volume 23
Issue 8
Pages 2461-2478
Keywords cancer, fatigue, review
Public URL
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