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Mismatch negativity (MMN) reveals inefficient auditory ventral stream function in chronic auditory comprehension impairments

Robson, Holly; Cloutman, Lauren; Keidel, James L.; Sage, Karen; Drakesmith, Mark; Welbourne, Stephen

Authors

Holly Robson h.v.robson@reading.ac.uk

Lauren Cloutman lauren.cloutman@manchester.ac.uk

James L. Keidel j.keidel@sussex.ac.uk

Karen Sage karen.sage@uwe.ac.uk

Mark Drakesmith drakesmithm@cf.ac.uk

Stephen Welbourne stephen.welbourne@manchester.ac.uk



Abstract

Background: Auditory discrimination is significantly impaired in Wernicke's aphasia (WA) and thought to be causatively related to the language comprehension impairment which characterises the condition. This study used mismatch negativity (MMN) to investigate the neural responses corresponding to successful and impaired auditory discrimination in WA. Methods: Behavioural auditory discrimination thresholds of consonant-vowel-consonant (CVC) syllables and pure tones (PTs) were measured in WA (n=7) and control (n=7) participants. Threshold results were used to develop multiple deviant MMNoddball paradigms containing deviants which were either perceptibly or non-perceptibly different from the standard stimuli. MMN analysis investigated differences associated with group, condition and perceptibility as well as the relationship between MMN responses and comprehension (within which behavioural auditory discrimination profiles were examined). Results: MMN waveforms were observable to both perceptible and non-perceptible auditory changes. Perceptibility was only distinguished by MMN amplitude in the PT condition. The WA group could be distinguished from controls by an increase in MMN response latency to CVC stimuli change. Correlation analyses displayed a relationship between behavioural CVC discrimination and MMN amplitude in the control group, where greater amplitude corresponded to better discrimination. The WA group displayed the inverse effect; both discrimination accuracy and auditory comprehension scores were reduced with increased MMN amplitude. In the WA group, a further correlation was observed between the lateralisation of MMN response and CVC discrimination accuracy; the greater the bilateral involvement the better the discrimination accuracy. Conclusions: The results from this study provide further evidence for the nature of auditory comprehension impairment in WA and indicate that the auditory discrimination deficit is grounded in a reduced ability to engage in efficient hierarchical processing and the construction of invariant auditory objects. Correlation results suggest that people with chronic WA may rely on an inefficient, noisy right hemisphere auditory stream when attempting to process speech stimuli. © 2014 Elsevier Ltd.

Journal Article Type Article
Publication Date Jan 1, 2014
Journal Cortex
Print ISSN 0010-9452
Electronic ISSN 1973-8102
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 59
Pages 113-125
APA6 Citation Robson, H., Cloutman, L., Keidel, J. L., Sage, K., Drakesmith, M., & Welbourne, S. (2014). Mismatch negativity (MMN) reveals inefficient auditory ventral stream function in chronic auditory comprehension impairments. Cortex, 59, 113-125. https://doi.org/10.1016/j.cortex.2014.07.009
DOI https://doi.org/10.1016/j.cortex.2014.07.009
Keywords mismatch negativity, MMN, stroke, Wernicke's aphasia, EEG
Publisher URL http://dx.doi.org/10.1016/j.cortex.2014.07.009

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