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Effect of mental challenge induced by movie clips on action potential duration in normal human subjects independent of heart rate

Child, Nicholas; Hanson, Ben; Bishop, Martin; Rinaldi, Christopher A.; Bostock, Julian; Western, David; Cooklin, Michael; O'Neil, Mark; Wright, Matthew; Razavi, Reza; Gill, Jaswinder; Taggart, Peter

Authors

Nicholas Child

Ben Hanson

Martin Bishop

Christopher A. Rinaldi

Julian Bostock

David Western David.Western@uwe.ac.uk
Wallscourt Fellow in Health Technology

Michael Cooklin

Mark O'Neil

Matthew Wright

Reza Razavi

Jaswinder Gill

Peter Taggart



Abstract

Background-Mental stress and emotion have long been associated with ventricular arrhythmias and sudden death in animal models and humans. The effect of mental challenge on ventricular action potential duration (APD) in conscious healthy humans has not been reported. Methods and Results-Activation recovery intervals measured from unipolar electrograms as a surrogate for APD (n=19) were recorded from right and left ventricular endocardium during steady-state pacing, whilst subjects watched an emotionally charged flm clip. To assess the possible modulating role of altered respiration on APD, the subjects then repeated the same breathing pattern they had during the stress, but without the movie clip. Hemodynamic parameters (mean, systolic, and diastolic blood pressure, and rate of pressure increase) and respiration rate increased during the stressful part of the flm clip (P=0.001). APD decreased during the stressful parts of the flm clip, for example, for global right ventricular activation recovery interval at end of flm clip 193.8 ms (SD, 14) versus 198.0 ms (SD, 13) during the matched breathing control (end flm left ventricle 199.8 ms [SD, 16] versus control 201.6 ms [SD, 15]; P=0.004). Respiration rate increased during the stressful part of the flm clip (by 2 breaths per minute) and was well matched in the respective control period without any hemodynamic or activation recovery interval changes. Conclusions-Our results document for the frst time direct recordings of the effect of a mental challenge protocol on ventricular APD in conscious humans. The effect of mental challenge on APD was not secondary to emotionally induced altered respiration or heart rate. © 2014 American Heart Association, Inc.

Journal Article Type Article
Publication Date Jan 1, 2014
Journal Circulation: Arrhythmia and Electrophysiology
Print ISSN 1941-3149
Electronic ISSN 1941-3084
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Volume 7
Issue 3
Pages 518-523
APA6 Citation Child, N., Hanson, B., Bishop, M., Rinaldi, C. A., Bostock, J., Western, D., …Taggart, P. (2014). Effect of mental challenge induced by movie clips on action potential duration in normal human subjects independent of heart rate. Circulation: Arrhythmia and Electrophysiology, 7(3), 518-523. https://doi.org/10.1161/CIRCEP.113.000909
DOI https://doi.org/10.1161/CIRCEP.113.000909
Publisher URL https://doi.org/10.1161/CIRCEP.113.000909
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