Michael R. Loebinger
Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: A cohort study
Loebinger, Michael R.; Clark, Samuel J.; Shaw, Emily C.; Nicholson, Andrew G.; Hansell, David M.; Hopkinson, Nick S.; Char, Anjali; Hansell, David M; Sedgwick, Philip; Wilson, Robert; Jordan, Simon
Authors
Samuel J. Clark
Emily C. Shaw
Andrew G. Nicholson
David M. Hansell
Nick S. Hopkinson
Anjali Char
David M Hansell
Philip Sedgwick
Robert Wilson
Simon Jordan
Abstract
© 2014 Char et al.; licensee BioMed Central Ltd. Background: Patients with COPD are at risk of non-tuberculous mycobacterial infection (NTM). This study examined the histology of lung tissue from COPD patients following lung volume reduction with particular focus on evidence of mycobacterial infection.Methods: Retrospective histological study of 142 consecutive lung volume reduction surgical specimens (126 separate patients) at Royal Brompton Hospital between 2000 - 2013, with prospectively collected preoperative data on exacerbation rate, lung function and body mass index.Results: 92% of patients had at least one other histological diagnosis in addition to emphysema. 10% of specimens had histological evidence of mycobacterial infection, one with co-existent aspergilloma. Mycobacteria were only identified in those patients with granulomas that were necrotising. These patients had higher exacerbation rates, lower TLCO and FEV 1 .Conclusion: A proportion of severe COPD patients will have evidence of mycobacterial infection despite lack of clinical and radiological suspicion. This may have implications for long-term management of these patients.
Journal Article Type | Article |
---|---|
Publication Date | Aug 2, 2014 |
Deposit Date | Aug 8, 2014 |
Publicly Available Date | Nov 15, 2016 |
Journal | BMC Pulmonary Medicine |
Electronic ISSN | 1471-2466 |
Publisher | BioMed Central |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 1 |
Pages | 1-7 |
DOI | https://doi.org/10.1186/1471-2466-14-124 |
Keywords | COPD, lung volume reduction surgery, mycobacterial |
Public URL | https://uwe-repository.worktribe.com/output/813788 |
Publisher URL | http://www.biomedcentral.com/1471-2466/14/124 |
Contract Date | Nov 15, 2016 |
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