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Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: A cohort study

Hansell, David M.; Hopkinson, Nick S.; Nicholson, Andrew G.; Shaw, Emily C.; Clark, Samuel J.; Loebinger, Michael R.; Hansell, David M; Char, Anjali; Sedgwick, Philip; Wilson, Robert; Jordan, Simon

Authors

David M. Hansell

Nick S. Hopkinson

Andrew G. Nicholson

Emily C. Shaw

Samuel J. Clark

Michael R. Loebinger

David M Hansell

Anjali Char

Philip Sedgwick

Robert Wilson

Simon Jordan



Abstract

© 2014 Char et al.; licensee BioMed Central Ltd. Background: Patients with COPD are at risk of non-tuberculous mycobacterial infection (NTM). This study examined the histology of lung tissue from COPD patients following lung volume reduction with particular focus on evidence of mycobacterial infection.Methods: Retrospective histological study of 142 consecutive lung volume reduction surgical specimens (126 separate patients) at Royal Brompton Hospital between 2000 - 2013, with prospectively collected preoperative data on exacerbation rate, lung function and body mass index.Results: 92% of patients had at least one other histological diagnosis in addition to emphysema. 10% of specimens had histological evidence of mycobacterial infection, one with co-existent aspergilloma. Mycobacteria were only identified in those patients with granulomas that were necrotising. These patients had higher exacerbation rates, lower TLCO and FEV 1 .Conclusion: A proportion of severe COPD patients will have evidence of mycobacterial infection despite lack of clinical and radiological suspicion. This may have implications for long-term management of these patients.

Journal Article Type Article
Publication Date Aug 2, 2014
Journal BMC Pulmonary Medicine
Electronic ISSN 1471-2466
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 14
Issue 1
Pages 1-7
APA6 Citation Loebinger, M. R., Clark, S. J., Shaw, E. C., Nicholson, A. G., Hansell, D. M., Hopkinson, N. S., …Loebinger, M. R. (2014). Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: A cohort study. BMC Pulmonary Medicine, 14(1), 1-7. https://doi.org/10.1186/1471-2466-14-124
DOI https://doi.org/10.1186/1471-2466-14-124
Keywords COPD, lung volume reduction surgery, mycobacterial
Publisher URL http://www.biomedcentral.com/1471-2466/14/124

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