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Live-birth rate associated with repeat in vitro fertilization treatment cycles

Smith, Andrew D. A. C.; Tilling, Kate; Nelson, Scott M.; Lawlor, Debbie A.

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Kate Tilling

Scott M. Nelson

Debbie A. Lawlor


© 2015 American Medical Association. All rights reserved. Importance The likelihood of achieving a live birth with repeat in vitro fertilization (IVF) is unclear, yet treatment is commonly limited to 3 or 4 embryo transfers. Objective To determine the live-birth rate per initiated ovarian stimulation IVF cycle and with repeated cycles. Design, Setting, and Participants Prospective study of 156 947 UKwomen who received 257 398 IVF ovarian stimulation cycles between 2003 and 2010 and were followed up until June 2012. Exposures In vitro fertilization, with a cycle defined as an episode of ovarian stimulation and all subsequent separate fresh and frozen embryo transfers. Main Outcomes and Measures Live-birth rate per IVF cycle and the cumulative live-birth rates across all cycles in all women and by age and treatment type. Optimal, prognosis-adjusted, and conservative cumulative live-birth rates were estimated, reflecting 0%, 30%, and 100%, respectively, of women who discontinued due to poor prognosis and having a live-birth rate of 0 had they continued. Results Among the 156 947 women, the median age at start of treatment was 35 years (interquartile range, 32-38; range, 18-55), and the median duration of infertility for all 257 398 cycles was 4 years (interquartile range, 2-6; range,


Smith, A. D. A. C., Tilling, K., Nelson, S. M., & Lawlor, D. A. (2015). Live-birth rate associated with repeat in vitro fertilization treatment cycles. Journal of the American Medical Association, 314(24), 2654-2662.

Journal Article Type Article
Acceptance Date Nov 19, 2015
Publication Date Dec 22, 2015
Deposit Date Dec 2, 2015
Publicly Available Date Oct 19, 2016
Journal JAMA - Journal of the American Medical Association
Print ISSN 0098-7484
Electronic ISSN 1538-3598
Publisher American Medical Association (AMA)
Peer Reviewed Peer Reviewed
Volume 314
Issue 24
Pages 2654-2662
Keywords IVF, in vitro fertilization, live births, birth rate
Public URL
Publisher URL
Additional Information Additional Information : The final publication is available at


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