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The tribulations of trials: Lessons learnt recruiting 777 older adults into REtirement in ACTion (REACT), a trial of a community, group-based active ageing intervention targeting mobility disability

Withall, Janet; Greaves, Colin J.; Thompson, Janice L.; de Koning, Jolanthe L.; Bollen, Jessica C.; Moorlock, Sarah J.; Fox, Kenneth R.; Western, Max J.; Snowsill, Tristan; Medina-Lara, Antonieta; Cross, Rosina; Ladlow, Peter; Taylor, Gordon; Zisi, Vasiliki; Clynes, James; Gray, Selena; Agyapong-Badu, Sandra; Guralnik, Jack M.; Rejeski, W. Jack; Stathi, Afroditi

The tribulations of trials: Lessons learnt recruiting 777 older adults into REtirement in ACTion (REACT), a trial of a community, group-based active ageing intervention targeting mobility disability Thumbnail


Authors

Janet Withall

Colin J. Greaves

Janice L. Thompson

Jolanthe L. de Koning

Jessica C. Bollen

Sarah J. Moorlock

Kenneth R. Fox

Max J. Western

Tristan Snowsill

Antonieta Medina-Lara

Rosina Cross

Peter Ladlow

Gordon Taylor

Vasiliki Zisi

James Clynes

Sandra Agyapong-Badu

Jack M. Guralnik

W. Jack Rejeski

Afroditi Stathi



Abstract

© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. BACKGROUND: Challenges of recruitment to randomized controlled trials (RCTs) and successful strategies to overcome them should be clearly reported to improve recruitment into future trials. REtirement in ACTion (REACT) is a United Kingdom-based multicenter RCT recruiting older adults at high risk of mobility disability to a 12-month group-based exercise and behavior maintenance program or to a minimal Healthy Aging control intervention. METHODS: The recruitment target was 768 adults, aged 65 years and older scoring 4-9 on the Short Physical Performance Battery (SPPB). Recruitment methods include the following: (a) invitations mailed by general practitioners (GPs); (b) invitations distributed via third-sector organizations; and (c) public relations (PR) campaign. Yields, efficiency, and costs were calculated. RESULTS: The study recruited 777 (33.9% men) community-dwelling, older adults (mean age 77.55 years (SD 6.79), mean SPPB score 7.37 (SD 1.56)), 95.11% white (n = 739) and broadly representative of UK quintiles of deprivation. Over a 20-month recruitment period, 25,559 invitations were issued. Eighty-eight percent of the participants were recruited via GP invitations, 5.4% via the PR campaign, 3% via word-of-mouth, and 2.5% via third-sector organizations. Mean recruitment cost per participant was £78.47, with an extra £26.54 per recruit paid to GPs to cover research costs. CONCLUSIONS: REACT successfully recruited to target. Response rates were lower than initially predicted and recruitment timescales required adjustment. Written invitations from GPs were the most efficient method for recruiting older adults at risk of mobility disability. Targeted efforts could achieve more ethnically diverse cohorts. All trials should be required to provide recruitment data to enable evidence-based planning of future trials.

Citation

Withall, J., Greaves, C. J., Thompson, J. L., de Koning, J. L., Bollen, J. C., Moorlock, S. J., …Stathi, A. (2020). The tribulations of trials: Lessons learnt recruiting 777 older adults into REtirement in ACTion (REACT), a trial of a community, group-based active ageing intervention targeting mobility disability. Journals of Gerontology, Series A, 75(12), 2387-2395. https://doi.org/10.1093/gerona/glaa051

Journal Article Type Article
Acceptance Date Feb 12, 2020
Online Publication Date Mar 9, 2020
Publication Date Dec 1, 2020
Deposit Date Aug 4, 2020
Publicly Available Date Nov 19, 2020
Journal The Journals of Gerontology: Series A
Print ISSN 1079-5006
Electronic ISSN 1758-535X
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 75
Issue 12
Pages 2387-2395
DOI https://doi.org/10.1093/gerona/glaa051
Keywords Ageing; Geriatrics and Gerontology; Physical activity; Physical function; Randomized control trial
Public URL https://uwe-repository.worktribe.com/output/6473392

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