Susan J. Tyler
α- and β-secretase: Profound changes in Alzheimer's disease
Tyler, Susan J.; Dawbarn, David; Allen, Shelley J.; Wilcock, Gordon
Authors
David Dawbarn
Shelley J. Allen
Gordon Wilcock
Abstract
The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of β-amyloid (Aβ) peptide, which is cleaved from Amyloid Precursor Protein (APP) by the enzyme β-secretase. Only small amounts of Aβ form in normal brain; more typically this is precluded by the processing of APP by α-secretase. Here, we describe a decrease in α-secretase (81% of normal) and a large increase in β-secretase activity (185%) in sporadic Alzheimer's disease temporal cortex. Since α-secretase is present principally in neurons known to be vulnerable in Alzheimer's disease, and there is known competition between α- and β-secretase for the substrate APP, it is significant that the majority of Alzheimer samples tested here were low in α-secretase. Eighty percent of Alzheimer brains examined had an increase in β-secretase, a decrease in α-secretase, or both; which may account for the means by which the majority of people develop Alzheimer's disease. © 2002 Elsevier Science (USA). All rights reserved.
Journal Article Type | Article |
---|---|
Publication Date | Dec 2, 2002 |
Journal | Biochemical and Biophysical Research Communications |
Print ISSN | 0006-291X |
Publisher | Elsevier |
Peer Reviewed | Not Peer Reviewed |
Volume | 299 |
Issue | 3 |
Pages | 373-376 |
DOI | https://doi.org/10.1016/S0006-291X%2802%2902635-9 |
Keywords | secretase, Alzheimer's disease |
Public URL | https://uwe-repository.worktribe.com/output/1075483 |
Publisher URL | http://dx.doi.org/10.1016/S0006-291X(02)02635-9 |
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