Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine

Morris, Roger H.K.; Tonks, Amanda J.; Jones, Kenneth P.; Jackson, Simon K.

Abstract

Platelet-activating factor (PAF) has a major role in inflammatory responses within the lung. This study investigates the effect of pulmonary surfactant on the synthesis of PAF in human monocytic cells. The pulmonary surfactant preparation Curosurf® significantly inhibited lipopolysaccharide (LPS)-stimulated PAF biosynthesis (P

• Journal Article Type: Article
• Publication Date: Jul 1, 2003
• Journal: Journal of Leukocyte Biology
• Print ISSN: 0741-5400
• Publisher: Society for Leukocyte Biology
• Peer Reviewed: Peer Reviewed
• Volume: 74
• Issue: 1
• Pages: 95-101
• DOI: https://doi.org/10.1189/jlb.1202601
• Keywords: platelet-activating, human monocytes, dipalmitoyl phosphatidylcholine
• Public URL: https://uwe-repository.worktribe.com/output/1069185
• Publisher URL: http://dx.doi.org/10.1189/jlb.1202601