Nociceptin/orphanin FQ modulates human T cell function in vitro

McLeod, Julie D.; Fulford, Allison J.; Purcell, Wendy M.; Waits, Paula S.

Abstract

Although nociceptin/orphanin FQ (N/OFQ) and its receptor (ORL-1) are widely distributed throughout the immune system, its role has yet to be elucidated. This study shows that N/OFQ (10-14-10-12 M) modulates T cell activation by up-regulating activation marker expression, e.g. CD28, leading to enhanced proliferation and modulation of TNFα secretion. However, on re-stimulated T cells N/OFQ causes inhibition of proliferation, which could be linked with N/OFQ up-regulating CTLA-4 expression. We have also shown that some of these effects are partly prostaglandin-dependent and that N/OFQ induces prostaglandin synthesis. This report suggests that N/OFQ could exert a key modulatory role in human T cell functions. © 2004 Elsevier B.V. All rights reserved.

Citation

Purcell, W. M., Fulford, A. J., McLeod, J. D., & Waits, P. S. (2004). Nociceptin/orphanin FQ modulates human T cell function in vitro. Journal of Neuroimmunology, 149(1-2), 110-120. https://doi.org/10.1016/j.jneuroim.2003.12.018

• Journal Article Type: Article
• Publication Date: Apr 1, 2004
• Journal: Journal of Neuroimmunology
• Print ISSN: 0165-5728
• Publisher: Elsevier
• Peer Reviewed: Not Peer Reviewed
• Volume: 149
• Issue: 1-2
• Pages: 110-120
• DOI: https://doi.org/10.1016/j.jneuroim.2003.12.018
• Keywords: nociceptin, T cell, prostaglandin, neuropeptides, activation markers
• Public URL: https://uwe-repository.worktribe.com/output/1062801
• Publisher URL: http://dx.doi.org/10.1016/j.jneuroim.2003.12.018