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Nociceptin/orphanin FQ modulates human T cell function in vitro

McLeod, Julie D.; Fulford, Allison J.; Purcell, Wendy M.; Waits, Paula S.


Julie D. McLeod

Allison J. Fulford

Wendy M. Purcell

Paula S. Waits


Although nociceptin/orphanin FQ (N/OFQ) and its receptor (ORL-1) are widely distributed throughout the immune system, its role has yet to be elucidated. This study shows that N/OFQ (10-14-10-12 M) modulates T cell activation by up-regulating activation marker expression, e.g. CD28, leading to enhanced proliferation and modulation of TNFα secretion. However, on re-stimulated T cells N/OFQ causes inhibition of proliferation, which could be linked with N/OFQ up-regulating CTLA-4 expression. We have also shown that some of these effects are partly prostaglandin-dependent and that N/OFQ induces prostaglandin synthesis. This report suggests that N/OFQ could exert a key modulatory role in human T cell functions. © 2004 Elsevier B.V. All rights reserved.


Purcell, W. M., Fulford, A. J., McLeod, J. D., & Waits, P. S. (2004). Nociceptin/orphanin FQ modulates human T cell function in vitro. Journal of Neuroimmunology, 149(1-2), 110-120.

Journal Article Type Article
Publication Date Apr 1, 2004
Journal Journal of Neuroimmunology
Print ISSN 0165-5728
Publisher Elsevier
Peer Reviewed Not Peer Reviewed
Volume 149
Issue 1-2
Pages 110-120
Keywords nociceptin, T cell, prostaglandin, neuropeptides, activation markers
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