Allison J. Fulford
Nociceptin/orphanin FQ modulates human T cell function in vitro
Fulford, Allison J.; McLeod, Julie D.; Purcell, Wendy M.; Waits, Paula S.
Authors
Julie D. McLeod
Wendy M. Purcell
Paula S. Waits
Abstract
Although nociceptin/orphanin FQ (N/OFQ) and its receptor (ORL-1) are widely distributed throughout the immune system, its role has yet to be elucidated. This study shows that N/OFQ (10-14-10-12 M) modulates T cell activation by up-regulating activation marker expression, e.g. CD28, leading to enhanced proliferation and modulation of TNFα secretion. However, on re-stimulated T cells N/OFQ causes inhibition of proliferation, which could be linked with N/OFQ up-regulating CTLA-4 expression. We have also shown that some of these effects are partly prostaglandin-dependent and that N/OFQ induces prostaglandin synthesis. This report suggests that N/OFQ could exert a key modulatory role in human T cell functions. © 2004 Elsevier B.V. All rights reserved.
Citation
Purcell, W. M., Fulford, A. J., McLeod, J. D., & Waits, P. S. (2004). Nociceptin/orphanin FQ modulates human T cell function in vitro. Journal of Neuroimmunology, 149(1-2), 110-120. https://doi.org/10.1016/j.jneuroim.2003.12.018
| Journal Article Type | Article |
|---|---|
| Publication Date | Apr 1, 2004 |
| Journal | Journal of Neuroimmunology |
| Print ISSN | 0165-5728 |
| Publisher | Elsevier |
| Peer Reviewed | Not Peer Reviewed |
| Volume | 149 |
| Issue | 1-2 |
| Pages | 110-120 |
| DOI | https://doi.org/10.1016/j.jneuroim.2003.12.018 |
| Keywords | nociceptin, T cell, prostaglandin, neuropeptides, activation markers |
| Public URL | https://uwe-repository.worktribe.com/output/1062801 |
| Publisher URL | http://dx.doi.org/10.1016/j.jneuroim.2003.12.018 |