Allison J. Fulford
Nociceptin/orphanin FQ modulates human T cell function in vitro
Fulford, Allison J.; McLeod, Julie D.; Purcell, Wendy M.; Waits, Paula S.
Julie D. McLeod
Wendy M. Purcell
Paula S. Waits
Although nociceptin/orphanin FQ (N/OFQ) and its receptor (ORL-1) are widely distributed throughout the immune system, its role has yet to be elucidated. This study shows that N/OFQ (10-14-10-12 M) modulates T cell activation by up-regulating activation marker expression, e.g. CD28, leading to enhanced proliferation and modulation of TNFα secretion. However, on re-stimulated T cells N/OFQ causes inhibition of proliferation, which could be linked with N/OFQ up-regulating CTLA-4 expression. We have also shown that some of these effects are partly prostaglandin-dependent and that N/OFQ induces prostaglandin synthesis. This report suggests that N/OFQ could exert a key modulatory role in human T cell functions. © 2004 Elsevier B.V. All rights reserved.
Purcell, W. M., Fulford, A. J., McLeod, J. D., & Waits, P. S. (2004). Nociceptin/orphanin FQ modulates human T cell function in vitro. Journal of Neuroimmunology, 149(1-2), 110-120. https://doi.org/10.1016/j.jneuroim.2003.12.018
|Journal Article Type||Article|
|Publication Date||Apr 1, 2004|
|Journal||Journal of Neuroimmunology|
|Peer Reviewed||Not Peer Reviewed|
|Keywords||nociceptin, T cell, prostaglandin, neuropeptides, activation markers|