The function of the bone marrow is known to be affected by both haematopoietic malignancies as well as the chemotherapy used to treat them. To appropriately evaluate the role of disease versus treatment, this study aimed to develop a novel three-dime... Read More about Development of a three-dimensional in-vitro model of the human bone marrow using commercially available matrices and bone marrow derived mesenchymal stem cells/HS-5 stromal cell line.
Outputs (5)
Iron overload cardiomyopathy (IOC) has been recently described as a dilated cardiomyopathy, characterized by left ventricular (LV) remodelling with chamber dilatation and reduced LV ejection fraction (LVEF). However, primary haemochromatosis, a genet... Read More about Investigations on potential digenic HAMP(hepcidin) and HFE haemochromatosis gene mutations in the development of iron overload in Irish patients with dilated cardiomyopathy.
Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography (2016)
Thesis
Generic methods were developed using different columns for analysis and purification of hydrophilic compounds by hydrophilic interaction chromatography (HILIC). Mobile phases were investigated in detail, and across each column chemistry tested (BEH A... Read More about Development of generic methods for the analysis and purification of polar compounds by high performance liquid chromatography.
Escherichia coli is a common human pathogen, capable of causing a wide range of infections. Some strains produce AmpC beta-lactamase, an enzyme able to affect the action of antibiotics. These strains are often resistant to cephalosporin antibiotics,... Read More about The molecular epidemiology of ampC-mediated resistance in Escherichia coli: A study of clinical strains isolated from the South West region.