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Outputs (8)

Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety (2011)
Journal Article

We have validated the use of prolonged inhalation of 7.5% carbon dioxide (CO2) as a human model of anxiety and have shown that drugs from two prototypical classes of anxiolytics, benzodiazepines and a serotonin reuptake inhibitor, attenuate CO2-induc... Read More about Preliminary evidence of anxiolytic effects of the CRF1 receptor antagonist R317573 in the 7.5% CO2 proof-of-concept experimental model of human anxiety.

Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression (2011)
Journal Article

Increased vigilance to threat-related stimuli is thought to be a core cognitive feature of anxiety. We sought to investigate the cognitive impact of experimentally induced anxiety, by means of a 7.5% CO2 challenge, which acts as an unconditioned anxi... Read More about Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression.