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Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 (2024)
Journal Article
Williams, A., Cooper, E., Clark, B., Perry, L., Ponassi, M., Iervasi, E., …Ladomery, M. (2024). Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3. International Journal of Molecular Sciences, 25(10), Article 5380. https://doi.org/10.3390/ijms25105380

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3- (trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound. GeGe-3 displays potent anti-angiogenic pr... Read More about Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3.

Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae (2022)
Book Chapter
Herman, A., Greenhough, A., & Gurevich, D. B. (2022). Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae. In VEGF Signaling (325-337). Humana Press. https://doi.org/10.1007/978-1-0716-2217-9_24

The transparent, genetically tractable zebrafish is increasingly recognized as a useful model to both live image and uncover mechanistic insight into cell interactions governing tissue homeostasis, pathology, and regeneration. Here, we describe a pro... Read More about Fluorescence-activated cell sorting and quantitative real-time PCR to reveal VEGF-expressing macrophage populations in the Zebrafish larvae.

5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis (2021)
Journal Article
Dixon, S. W., Collard, T. J., Mortensson, E. M. H., Legge, D. N., Chambers, A. C., Greenhough, A., …Williams, A. C. (2021). 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis. British Journal of Cancer, 124, 1959–1969. https://doi.org/10.1038/s41416-021-01354-5

Background: Most colorectal cancers (CRC) arise sporadically from precursor lesions: colonic polyps. Polyp resection prevents progression to CRC. Risk of future polyps is proportional to the number and size of polyps detected at screening, allowing i... Read More about 5-aminosalicylic acid inhibits stem cell function in human adenoma derived cells: Implications for chemoprophylaxis in colorectal tumorigenesis.